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Showing 1–8 of 8 results
Advanced filters: Author: Chloë Roustan Clear advanced filters

  • The SARS-CoV-2 spike has been evolving in the human population. The variants of concern alpha and beta evolved to optimise spike openness and so ability to bind its receptor ACE2, the affinity towards the receptor, and stability upon receptor binding.

    • Antoni G. Wrobel
    • Donald J. Benton
    • Steven J. Gamblin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-7

  • Here, the authors characterise the binding and neutralisation properties of CR3022, a neutralising Ab isolated from a convalescent SARS patient, against SARS-CoV-2 spike trimers and show using Cryo-EM the disruption of SARS-CoV-2 spike by CR3022 Fab.

    • Antoni G. Wrobel
    • Donald J. Benton
    • Steven J. Gamblin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-5

  • It has been suggested that pangolin coronaviruses may be the origin of SARS-CoV-2. Here the authors show that the Pangolin-CoV spike is structurally closely related to the closed form of SARS-CoV-2 spike and exhibits similar binding properties to human and pangolin ACE2; although neither spike binds bat ACE2.

    • Antoni G. Wrobel
    • Donald J. Benton
    • Steven J. Gamblin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-6

  • In this paper, the authors use hydrogen-deuterium exchange mass spectrometry to describe how the SARS-CoV-2 spike glycoprotein has evolved its structural dynamics features and receptor binding capability from the emergence of the original Wuhan isolate to the recent omicron variant. The findings reported shed light on the evolution of SARS-CoV-2 in the human population and the mechanisms of emergence of new variants.

    • Valeria Calvaresi
    • Antoni G. Wrobel
    • Argyris Politis
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Cryo-electron microscopy structures of consecutive binding events of ACE2 in complex with the spike protein of SARS-CoV-2 reveal the mechanisms of receptor binding by the spike protein and activation for membrane fusion by the spike protein of SARS-CoV-2.

    • Donald J. Benton
    • Antoni G. Wrobel
    • Steven J. Gamblin
    Research
    Nature
    Volume: 588, P: 327-330

  • Older people have suboptimal responses to primary series vaccines, which can place them at risk for adverse coronavirus disease 2019 outcomes. Here the authors show that booster vaccines provide a substantial increase in antibody levels in the short term but that there is significant waning 100 d after booster shots.

    • Gokhan Tut
    • Tara Lancaster
    • Paul Moss
    ResearchOpen Access
    Nature Aging
    Volume: 3, P: 93-104