Guglielmetti et al. show the potential for monitoring response to immunomodulatory treatment in a model of multiple sclerosis using hyperpolarized 13C metabolic MRI. The authors observe reduced pyruvate-to-lactate flux in vivo after treatment with fingolimod or dimethyl fumarate, as well as changes in immune cell populations.
- Caroline Guglielmetti
- Christian Cordano
- Myriam M. Chaumeil