Chronic rhinosinusitis with nasal polyps generally has a type 2 inflammatory eosinophilic profile but can have a treatment resistant neutrophilic phenotype. Here the authors characterise nasal polyps using single cell sequencing and spatial transcriptomics and show granzyme K+CD8+ T cells associated with neutrophilic inflammation which promote release of neutrophilic chemoattractants from fibroblasts.
- Cui-Lian Guo
- Chong-Shu Wang
- Zheng Liu
