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Showing 1–6 of 6 results
Advanced filters: Author: Chris H. Habrian Clear advanced filters

  • Combined single-molecule spectroscopy, hydrogen–deuterium exchange and molecular dynamics approaches reveal that agonist activation of metabotropic glutamate receptors entails population of several intermediary states before G protein coupling.

    • Naomi R. Latorraca
    • Sam Sabaat
    • Ehud Y. Isacoff
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 21, P: 1433-1443

  • We propose a model for a sequential, multistep activation mechanism of metabotropic glutamate receptor subtype 5, including a series of structures in lipid nanodiscs, from inactive to fully active, with agonist-bound intermediate states.

    • Kaavya Krishna Kumar
    • Haoqing Wang
    • Brian K. Kobilka
    Research
    Nature
    Volume: 629, P: 951-956

  • The molecular basis of functional diversity between obligatorily dimeric mGluRs is not understood. The authors show that functional differences typically attributed to differences in the agonist binding pocket emerge from differences between homomeric and heteromeric Group II and III Gi-coupled mGluRs in dimerization interface interactions.

    • Chris Habrian
    • Naomi Latorraca
    • Ehud Y. Isacoff
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • N-Methyl-D-aspartate receptors (NMDARs) activation involves closure of the GluN1 and GluN2 subunit ligand binding domains, which is regulated allosterically by the amino-terminal domain (ATD). Here, smFRET, used to monitor conformational rearrangements of the NMDAR ATD, reveals that glutamate binding to GluN2 subunits elicits two identical, sequential steps of ATD dimer separation that are regulated by protons.

    • Vojtech Vyklicky
    • Cherise Stanley
    • Ehud Y. Isacoff
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Metabotropic glutamate receptors (mGluRs) are dimeric G-protein–coupled receptors that operate at neural synapses. Here authors use FRET assays in live cells to monitor mGluR2/7’s activation and reveal how heterodimerization can alter the glutamate response of an mGluR.

    • Chris H. Habrian
    • Joshua Levitz
    • Ehud Y. Isacoff
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13