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Showing 1–6 of 6 results
Advanced filters: Author: Chris Summerfield Clear advanced filters
  • Richard Houlston and colleagues identify variants at six loci associated with risk of chronic lymphocytic leukemia. These findings confirm that common, low-penetrance susceptibility alleles contribute to this hematological malignancy and provide new insights into disease etiology.

    • Maria Chiara Di Bernardo
    • Dalemari Crowther-Swanepoel
    • Richard S Houlston
    Research
    Nature Genetics
    Volume: 40, P: 1204-1210
  • Humans strive to design safe AI systems that align with our goals and remain under our control. However, as AI capabilities advance, we face a new challenge: the emergence of deeper, more persistent relationships between humans and AI systems. We explore how increasingly capable AI agents may generate the perception of deeper relationships with users, especially as AI becomes more personalised and agentic. This shift, from transactional interaction to ongoing sustained social engagement with AI, necessitates a new focus on socioaffective alignment—how an AI system behaves within the social and psychological ecosystem co-created with its user, where preferences and perceptions evolve through mutual influence. Addressing these dynamics involves resolving key intrapersonal dilemmas, including balancing immediate versus long-term well-being, protecting autonomy, and managing AI companionship alongside the desire to preserve human social bonds. By framing these challenges through a notion of basic psychological needs, we seek AI systems that support, rather than exploit, our fundamental nature as social and emotional beings.

    • Hannah Rose Kirk
    • Iason Gabriel
    • Scott A. Hale
    Comments & OpinionOpen Access
    Humanities and Social Sciences Communications
    Volume: 12, P: 1-9