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Showing 1–3 of 3 results
Advanced filters: Author: Christelle Retiere Clear advanced filters

  • Myelodysplastic syndromes are characterised by clonal haematopoiesis, with the affected cells often harbouring mutations in the TET2 gene, an important regulator of DNA methylation state. Here authors show that the same mutations are also found in NK cells, perturbing their DNA methylation pattern and cytolytic function.

    • Maxime Boy
    • Valeria Bisio
    • Nicolas Dulphy
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • KIR2DL2 and KIR2DL3 are two inhibitory members of the killer-cell immunoglobulin-like receptors (KIR) family that share a common HLA-I preference in binding HLA from the C1 group. However, it is still unclear to what extent binding and function is equivalent between KIR2DL2 and 2DL3. Here, the authors present the crystal structures of KIR2DL2 and 2DL3 in complex with HLA-C*07:02 and observe differences in HLA-C recognition between KIR2DL2 and 2DL3, which correlates with differences in HLA-C binding preference as they show with mutagenesis and binding studies.

    • Shoeib Moradi
    • Sanda Stankovic
    • Julian P. Vivian
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11