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Showing 1–12 of 12 results
Advanced filters: Author: Christer S. Ejsing Clear advanced filters

  • Targeted mass spectrometry enables reproducible and accurate lipid quantification but dedicated software tools to develop targeted lipidomics assays are lacking. Here, the authors develop a targeted lipidomics workbench and lipid knowledgebase for the streamlined generation of targeted assays.

    • Bing Peng
    • Dominik Kopczynski
    • Robert Ahrends
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • The rapid increase in lipidomic data has triggered a community-based movement to develop guidelines and minimum requirements for generating, reporting and publishing lipidomic data. The creation of a dynamic checklist summarizing key details of lipidomic analyses using a common language has the potential to harmonize the field by improving both traceability and reproducibility.

    • Jeffrey G. McDonald
    • Christer S. Ejsing
    • Kim Ekroos
    Comments & Opinion
    Nature Metabolism
    Volume: 4, P: 1086-1088

  • Mutations near the ORMDL3 gene have been associated with childhood asthma. Here, in yeast, Orm proteins are shown to function in sphingolipid homeostasis; alterations in this control result in misregulation of sphingolipid production and accumulation of toxic metabolites. This raises the testable hypothesis that misregulation of sphingolipids may directly contribute to the development of asthma.

    • David K. Breslow
    • Sean R. Collins
    • Jonathan S. Weissman
    Research
    Nature
    Volume: 463, P: 1048-1053

  • Motile cells must navigate complex environments. Here the authors use state-of-the-art imaging, coarse-grained MD simulations and experimental biophysics to show that cells sense their plasma membrane curvature to circumvent obstacles.

    • Ewa Sitarska
    • Silvia Dias Almeida
    • Alba Diz-Muñoz
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • A quantitative genetic interaction map, or E-MAP, of ∼400 genes involved in plasma membrane biology, in combination with triplet genetic motif analysis, has led to the identification of a new component of the eisosome, Eis1, links the poorly characterized EMP70 gene to endocytic and eisosome functions, and uncovers a link between Rom2—a GDP/GTP exchange factor for Rho1 and Rho2—and the regulation of sphingolipid metabolism.

    • Pablo S Aguilar
    • Florian Fröhlich
    • Tobias C Walther
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 901-908

  • Modern mass spectrometric technologies provide quantitative readouts for a wide variety of lipid specimens. However, many studies do not report absolute lipid concentrations and differ vastly in methodologies, workflows and data presentation. Therefore, we encourage researchers to engage with the Lipidomics Standards Initiative to develop common standards for minimum acceptable data quality and reporting for lipidomics data, to take lipidomics research to the next level.

    • Gerhard Liebisch
    • Robert Ahrends
    • Kim Ekroos
    Comments & Opinion
    Nature Metabolism
    Volume: 1, P: 745-747