Mutations affecting sialylation and galactosylation affect megakaryocyte function and thrombopoiesis. Here the authors show that the enzyme β4GalT1 regulates thrombopoiesis and hematopoietic stem cell homeostasis by controlling beta-1 integrin function.
- Silvia Giannini
- Melissa M. Lee-Sundlov
- Karin M. Hoffmeister
