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Showing 1–8 of 8 results
Advanced filters: Author: Christian Büll Clear advanced filters

  • Here, the authors discover small molecules that inhibit glycosylation processes that occur in the Golgi apparatus of cells. The molecules reversibly inhibit formation of elaborate glycan structures without affecting secretion of glycoproteins.

    • Daniel Madriz Sørensen
    • Christian Büll
    • Yoshiki Narimatsu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Mucins play critical roles in maintaining the human microbiome, with their O-glycosylated tandem repeats (TRs) providing important cues for microbiota. Here, the authors develop a cellular platform for producing TRs with defined O-glycan structures to dissect the functions of TR O-glycosylation.

    • Rebecca Nason
    • Christian Büll
    • Yoshiki Narimatsu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Mucins are glycosylated proteins with important biological functions such as protection. Although glycopeptidases can cleave them, dedicated hydrolytic enzymes specific for mucins were unknown. Now microbial mucinases are discovered that specifically recognize mucin O-glycan clusters and employ two glutamic acid residues for catalytic cleavage.

    • Yoshiki Narimatsu
    • Christian Büll
    • Ramon Hurtado-Guerrero
    Research
    Nature Catalysis
    Volume: 7, P: 386-400

  • MacDonald et al. show that EGF triggers de-sialylation of plasma membrane glycoproteins like integrins in a mechanism that depends on the Na+/H+ antiporter NHE1 and the neuraminidases Neu1 and Neu3. Integrins are trafficked to the Golgi and re-sialylated.

    • Ewan MacDonald
    • Alison Forrester
    • Ludger Johannes
    Research
    Nature Cell Biology
    Volume: 27, P: 449-463

  • It is believed that human Influenza HA glycoprotein attaches to alpha2-6 linked sialic acids (SA) on cells, while avian viruses bind to alpha2-3 linked sialic acids, therewith contributing to host tropism. Here, Liu et al. show that mixing low-affinity alpha2-3 SA with low amounts of high-affinity alpha2-6 SA increases binding and entry of human viruses and the converse for avian virus. This shows that receptor recognition is not as strict as currently assumed and provides evidence that heteromultivalent interactions between human/avian HA and SA contributes to host adaptation.

    • Mengying Liu
    • Liane Z. X. Huang
    • Erik de Vries
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Saponin-based adjuvants are being explored as vaccine components as they induce high levels of antigen cross-presentation, but it is unknown how. Here the authors show that these adjuvants enhance cross-presentation by driving production of lipid bodies inside CD11b dendritic cells.

    • Martijn H. den Brok
    • Christian Büll
    • Gosse J. Adema
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14