It has been controversial whether the ependymal cells that line cerebral ventricles can generate neurons in the adult brain. This study reports that Notch signaling keeps ependymal cells in their differentiated state under normal circumstances. After an ischemic stroke, however, these cells can de-differentiate and generate both neuroblasts and astrocytes.
- Marie Carlén
- Konstantinos Meletis
- Jonas Frisén
