Nature Search

Molecular biomarkers for urothelial carcinoma of the bladder: challenges in clinical use

The integration of molecular biomarkers into prediction models has the potential to improve the management of urothelial carcinoma of the bladder. Bolenz and Lotan outline the search for candidate biomarkers in this disease, and discuss the obstacles to their use in routine clinical practice.

Christian Bolenz
Yair Lotan
Reviews01 Dec 2008
Nature Clinical Practice Urology

Volume: 5, P: 676-685
Loss of p190A RhoGAP induces aneuploidy and enhances bladder cancer cell migration and invasion by modulating actin dynamics

Qianyu Kang
Xue Kong
Cagatay Günes
ResearchOpen Access18 Nov 2025
Scientific Reports

Volume: 15, P: 1-15
Xpert bladder cancer monitor to predict the need for a second TURB (MoniTURB trial)

Johannes Breyer
Markus Eckstein
Maximilian C. Kriegmair
ResearchOpen Access18 Sept 2023
Scientific Reports

Volume: 13, P: 1-10
Subtype specific expression and survival prediction of pivotal lncRNAs in muscle invasive bladder cancer

Sebastien Rinaldetti
Thomas Stefan Worst
Philipp Erben
ResearchOpen Access24 Nov 2020
Scientific Reports

Volume: 10, P: 1-9
Pre-treatment metastatic biopsy: a step towards precision oncology for urothelial cancer

Metastatic urothelial cancer exhibits substantial molecular heterogeneity compared with the primary tumour, complicating the development of accurate biomarkers. Pre-treatment metastatic biopsies capture real-time tumour biology and can enhance response predictions for targeted therapies, improving patient selection for precision oncology.

Niklas Klümper
Alexander Cox
Markus Eckstein
Reviews29 Oct 2024
Nature Reviews Urology

Volume: 22, P: 256-267
Correction: Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells

Ramona Willbold
Katharina Wirth
Rainer Wittig
Amendments and CorrectionsOpen Access12 Feb 2020
Cell Death & Disease

Volume: 11, P: 1
Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor

Sospeter N. Njeru
Johann Kraus
K. Lenhard Rudolph
Research28 Oct 2019
Oncogene

Volume: 39, P: 1445-1465
Implications of TERT promoter mutations and telomerase activity in urothelial carcinogenesis

In this Perspectives, the authors present a new model of urothelial carcinogenesis that incorporates the role of telomerase activation. They also highlight the potential of targeting telomerase as a therapeutic approach for bladder cancer.

Cagatay Günes
Felix Wezel
Christian Bolenz
Reviews29 Mar 2018
Nature Reviews Urology

Volume: 15, P: 386-393
Deep learning-based classification of blue light cystoscopy imaging during transurethral resection of bladder tumors

Nairveen Ali
Christian Bolenz
Thomas Bocklitz
ResearchOpen Access02 Jun 2021
Scientific Reports

Volume: 11, P: 1-10
CDKN2A as transcriptomic marker for muscle-invasive bladder cancer risk stratification and therapy decision-making

Thomas S. Worst
Cleo-Aron Weis
Philipp Erben
ResearchOpen Access26 Sept 2018
Scientific Reports

Volume: 8, P: 1-10
Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells

Ramona Willbold
Katharina Wirth
Rainer Wittig
ResearchOpen Access09 Aug 2019
Cell Death & Disease

Volume: 10, P: 1-14

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Molecular biomarkers for urothelial carcinoma of the bladder: challenges in clinical use

Loss of p190A RhoGAP induces aneuploidy and enhances bladder cancer cell migration and invasion by modulating actin dynamics

Xpert bladder cancer monitor to predict the need for a second TURB (MoniTURB trial)

Subtype specific expression and survival prediction of pivotal lncRNAs in muscle invasive bladder cancer

Pre-treatment metastatic biopsy: a step towards precision oncology for urothelial cancer

Correction: Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells

Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor

Implications of TERT promoter mutations and telomerase activity in urothelial carcinogenesis

Deep learning-based classification of blue light cystoscopy imaging during transurethral resection of bladder tumors

CDKN2A as transcriptomic marker for muscle-invasive bladder cancer risk stratification and therapy decision-making

Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells

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