CLYBL has a role beyond itaconate catabolism to degrade malyl-CoA, a noncanonical metabolite and methylmalonyl-CoA mutase inhibitor that depletes coenzyme B12, implying that malyl-CoA contributes to the B12 deficiency observed in individuals with CLYBL loss of function.
- Corey M. Griffith
- Jean-François Conrotte
- Carole L. Linster