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Showing 1–25 of 25 results
Advanced filters: Author: Christian Gaebler Clear advanced filters

  • Here, the authors develop Q4ddPCR, a high-throughput assay to quantify genetically intact HIV reservoirs by targeting four regions, and demonstrate that it reduces assay dropout to 5%, tracks reservoir decay, and closely correlates with viral outgrowth.

    • Rachel Scheck
    • Mark Melzer
    • Christian Gaebler
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-14

  • When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

    • Balazs Aczel
    • Barnabas Szaszi
    • Brian A. Nosek
    Research
    Nature
    Volume: 652, P: 135-142

  • This work describes three people living with HIV-1 who maintain long-term immune-mediated control of HIV-1 after pausing antiretroviral therapy. Autologous neutralizing antibodies and polyfunctional HIV-1-specific CD4+ and CD8+ T cell responses, pre-programmed for antigen response, were present before, and persisted during, ART interruption. This serves as a model of ART-free control of HIV-1 and informs new HIV-1 cure strategies.

    • Katie Fisher
    • Mauro A. Garcia
    • Ole S. Søgaard
    ResearchOpen Access
    Nature Immunology
    Volume: 27, P: 812-826

  • HIV remission of more than 6 years was achieved in a patient with functional viral co-receptors after CCR5 wild-type/Δ32 allogeneic stem cell transplantation, providing evidence of other mechanisms that can be harnessed to attain long-term remission.

    • Christian Gaebler
    • Samad Kor
    • Olaf Penack
    ResearchOpen Access
    Nature
    Volume: 650, P: 701-709

  • The Moderna (mRNA-1273) and Pfizer–BioNTech (BNT162b2) vaccines elicit anti-RBD antibodies similar to those elicited through natural infection with SARS-CoV-2, but their potent neutralizing activity was reduced or abolished by new viral variants of concern.

    • Zijun Wang
    • Fabian Schmidt
    • Michel C. Nussenzweig
    Research
    Nature
    Volume: 592, P: 616-622

  • Although rare, antibodies against the receptor-binding domain of SARS-CoV-2 that showed potent antiviral activity were obtained from all tested convalescent individuals, suggesting that a vaccine designed to elicit such antibodies could be broadly effective.

    • Davide F. Robbiani
    • Christian Gaebler
    • Michel C. Nussenzweig
    Research
    Nature
    Volume: 584, P: 437-442

  • In a cohort of 87 individuals with COVID-19, the memory B cell response at 6.2 months after the onset of disease evolves in a manner that is consistent with the persistence of SARS-CoV-2 antigen.

    • Christian Gaebler
    • Zijun Wang
    • Michel C. Nussenzweig
    Research
    Nature
    Volume: 591, P: 639-644

  • Quantifying intact proviruses is key to understanding decreases in HIV reservoirs but results can differ depending on the method. To balance sensitivity and specificity of two assays, the authors use mathematical models and measurements of intact and defective proviruses to assess how misclassification can impact estimates of natural and therapeutic reservoir reduction.

    • Daniel B. Reeves
    • Christian Gaebler
    • Michel C. Nussenzweig
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • Witte et al show that previously acquired substitutions in the SARS-CoV-2 spike protein enable the acquisition of new antibody escape substitutions. New and old substitutions interact to enable escape from broadly neutralizing antibodies.

    • Leander Witte
    • Viren A. Baharani
    • Paul D. Bieniasz
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Individual memory antibodies selected over time by natural infection with SARS-CoV-2 have greater potency and breadth than antibodies elicited by vaccination, whereas the overall neutralizing potency of plasma is greater following vaccination.

    • Alice Cho
    • Frauke Muecksch
    • Michel C. Nussenzweig
    ResearchOpen Access
    Nature
    Volume: 600, P: 517-522

  • A complex range of mutations within the SARS-CoV-2 spike protein is needed to escape polyclonal plasma neutralizing antibodies, and plasma from individuals who were first infected then vaccinated display the greatest resilience to escape mutations.

    • Fabian Schmidt
    • Yiska Weisblum
    • Paul D. Bieniasz
    Research
    Nature
    Volume: 600, P: 512-516

  • West and colleagues develop the Variant Database software tool for examination of changing Spike mutations in SARS-CoV-2 genomes. The authors use this to detect emerging lineages of SARS-CoV-2 in New York and report the rapid spread of the B.1.526 lineage in the city.

    • Anthony P. West Jr.
    • Joel O. Wertheim
    • Pamela J. Bjorkman
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Pre-existing high-affinity antibodies alter germinal centre and memory B cell selection by lowering the activation threshold for B cells and through direct masking of their cognate epitopes, thereby permitting a diverse set of abundant lower-affinity clones targeting alternate epitopes to participate in the immune response.

    • Dennis Schaefer-Babajew
    • Zijun Wang
    • Michel C. Nussenzweig
    ResearchOpen Access
    Nature
    Volume: 613, P: 735-742

  • Here, the authors show in a cohort of people with HIV, COVID mRNA vaccination is followed by a transient boost in a particular profile of HIV-specific T-cell responses and a corresponding decrease in residual HIV RNA – suggesting productive immune engagement with infected cells.

    • Eva M. Stevenson
    • Sandra Terry
    • R. Brad Jones
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • A clinical study shows that immunotherapy with anti-HIV-1 antibodies maintains prolonged viral suppression after anti-retroviral treatment is discontinued and affects the size and composition of the intact but not the defective proviral reservoir.

    • Christian Gaebler
    • Lilian Nogueira
    • Michel C. Nussenzweig
    ResearchOpen Access
    Nature
    Volume: 606, P: 368-374

  • Leading COVID-19 vaccine candidates have progressed through laboratory tests at record speed. Two early clinical trials suggest that immunization delivers a favourable immune response and safety profile, but questions remain.

    • Christian Gaebler
    • Michel C. Nussenzweig
    News & Views
    Nature
    Volume: 586, P: 501-502