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Showing 1–4 of 4 results
Advanced filters: Author: Christian Gampe Clear advanced filters

  • Bicyclo[1.1.1]pentanes are of interest to the pharmaceutical and chemical communities, due largely to their metabolic stability and potential as bioisosteres. Here the enantioselective C–H activation of these carbocycles is reported, giving access to enantioenriched, substituted products while maintaining the carbocyclic framework.

    • Zachary J. Garlets
    • Jacob N. Sanders
    • Huw M. L. Davies
    Research
    Nature Catalysis
    Volume: 3, P: 351-357

  • Here the authors use phage display to develop cystine-knot peptides that inhibit the trimeric serine protease HTRA1. Structural and biochemical characterisation uncovered binding of the peptides to a cryptic pocket that locked the active site in a noncompetent state.

    • Yanjie Li
    • Yuehua Wei
    • Daniel Kirchhofer
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Most DNA-encoded library (DEL) syntheses are limited by the presence of sensitive DNA-based constructs. Here, the authors develop DOSEDO, a diverse 3.7 million compound DEL, generated through diversity-oriented synthesis that provides enhanced scaffold and exit vector diversity and gives validated binding hits for multiple protein targets.

    • Liam Hudson
    • Jeremy W. Mason
    • Karin Briner
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15