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Showing 1–13 of 13 results
Advanced filters: Author: Christian Hoppmann Clear advanced filters

  • Many genetic loci have been identified to be associated with kidney disease, but the molecular mechanisms are not well understood. Here, the authors perform epigenome-wide association studies on kidney function measures to identify epigenetic marks and pathways involved in kidney function.

    • Pascal Schlosser
    • Adrienne Tin
    • Alexander Teumer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Serum urate concentration can be studied in large datasets to find genetic and epigenetic loci that may be related to cardiometabolic traits. Here the authors identify and replicate 100 urate-associated CpGs, which provide insights into urate GWAS loci and shared CpGs of urate and cardiometabolic traits.

    • Adrienne Tin
    • Pascal Schlosser
    • Anna Köttgen
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Urinary albumin-to-creatinine ratio (UCAR) is associated with various clinical outcomes such as kidney disease and cardiovascular disease. Here, the authors report genome-wide meta-analysis in over 500,000 individuals and find 68 UACR loci, followed by statistical fine-mapping, gene prioritization and experimental validation in flies.

    • Alexander Teumer
    • Yong Li
    • Anna Köttgen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • This study reports the discovery of dense sponge gardens across the peaks of permanently ice-covered, extinct volcanic seamounts of the Langseth Ridge and on the remnants of a now extinct seep ecosystem. Using approaches to sample and infer food and energy sources to this ice-covered community, the authors suggest that the sponges use refractory organic matter trapped in the extinct seep community on which they sit.

    • T. M. Morganti
    • B. M. Slaby
    • A. Boetius
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • A trans-ancestry genome-wide association study of serum urate levels identifies 183 loci influencing this trait. Enrichment analyses, fine-mapping and colocalization with gene expression in 47 tissues implicate the kidney and liver as key target organs and prioritize potential causal genes.

    • Adrienne Tin
    • Jonathan Marten
    • Anna Köttgen
    Research
    Nature Genetics
    Volume: 51, P: 1459-1474

  • A genetically encoded unnatural amino acid analog and its acidic deprotection enable the site-specific incorporation of phosphotyrosine (pTyr) into proteins such as ubiquitin, where it can be used to study the function of this phosphorylated residue.

    • Christian Hoppmann
    • Allison Wong
    • Lei Wang
    Research
    Nature Chemical Biology
    Volume: 13, P: 842-844

  • The success of a fluorescent dye as a molecular probe to monitor the intracellular activity of biomolecules depends on its physicochemical characteristics. Here, the authors use a predictive model to identify key features that allow them to design cell permeable, background-free fluorescent probes.

    • Samira Husen Alamudi
    • Rudrakanta Satapathy
    • Young-Tae Chang
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • Water isotope modelling is an important tool in climate reconstructions, but there remain gaps in our understanding of the effects upon oxygen and hydrogen isotope fractionation, and thus the source of the deposited signal. Here, the authors present a dataset assembled over two years that shows deuterium excess is controlled by humidity and sea surface temperature, and oxygen and hydrogen isotopes as well as deuterium excess are controlled by sublimation of snow in sea-ice regions.

    • Jean-Louis Bonne
    • Melanie Behrens
    • Martin Werner
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10