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Showing 1–3 of 3 results
Advanced filters: Author: Christian Kramme Clear advanced filters

  • CRISPR enzymes require a defined protospacer adjacent motif (PAM) which can be limiting for editing applications. Here the authors recombine the PAM-interacting domain of SpRY with the N-terminus of Sc + + to generate a chimeric enzyme with highly flexible PAM preference: SpRYc.

    • Lin Zhao
    • Sabrina R. T. Koseki
    • Pranam Chatterjee
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-8

  • Pranam Chatterjee et al. present a novel computational platform for engineering peptide fusions that bind to the SARS-CoV-2 spike protein and tag it for proteasomal degradation. They experimentally validate an optimal variant in human cells, showing that it inhibits production of infection-competent virus.

    • Pranam Chatterjee
    • Manvitha Ponnapati
    • Joseph M. Jacobson
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-8