Severe SARS-CoV-2 infection and COVID-19 can associate with autoantibodies neutralizing inflammatory cytokines. The authors here investigate the presence of autoantibodies targeting specific anti-inflammatory mediators. They identify severe COVID-19 to associate with autoantibodies depleting IL-1Ra and PGRN, which coincide with hyperphosphorylated antigen isoforms induced by inflammatory stress.
- Lorenz Thurner
- Natalie Fadle
- Christoph Kessel