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Showing 1–4 of 4 results
Advanced filters: Author: Christian Neander Clear advanced filters

  • Phenotypic and functional heterogeneity of cancer associated fibroblasts (CAFs) has been reported in pancreatic ductal adenocarcinoma (PDAC). Here the authors show that epithelial MAPK activity promotes myofibroblastic differentiation of CAFs. Furthermore, the epithelial basal-like subtype is associated with a CAF phenotype characterized by elevated MAPK activity and TGF-β signalling, associated with T cell exclusion in PDAC.

    • Lisa Veghini
    • Davide Pasini
    • Vincenzo Corbo
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Immune responses to pancreatic ductal adenocarcinoma can be inhibited by cancer cells. Here the authors show that high levels of progranulin in PDAC inhibits immune responses by reducing MHC class I antigen presentation through enhanced degradation of MHC class I via autophagy.

    • Phyllis F. Cheung
    • JiaJin Yang
    • Jens T. Siveke
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • The size and shape of the inner ear, or bony labyrinth, is thought to be related to ecological adaptations in vertebrates. Here, the authors examine this relationship in turtles across 230 million years of evolution, unexpectedly finding large labyrinth size and no association with ecology.

    • Serjoscha W. Evers
    • Walter G. Joyce
    • Roger B. J. Benson
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15