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Showing 1–5 of 5 results
Advanced filters: Author: Christian O. Bretschneider Clear advanced filters

  • Hyperpolarization of nuclear spins for enhancing the sensitivity of magnetic resonance can typically be achieved at low temperatures. Here, the authors demonstrate room-temperature polarization of 13C derived from optically pumped electrons of nitrogen vacancies in diamonds with arbitrary orientations.

    • Gonzalo A. Álvarez
    • Christian O. Bretschneider
    • Lucio Frydman
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • Polyketide synthases make use of a limited set of enzymes to create diverse natural products. The discovery that a ketosynthase homolog catalyzes ester bond formation instead of the typical Claisen condensation uncovers a previously unknown mechanism to generate chemical diversity.

    • Tom Bretschneider
    • Georg Zocher
    • Christian Hertweck
    Research
    Nature Chemical Biology
    Volume: 8, P: 154-161

  • This study shows the structural and biochemical characterization of a new type of polyketide synthase module that catalyses the vinylogous addition of a malonyl unit to an unsaturated thioester, generating a branch in the growing polyketide chain; this characterization provides a mechanism by which the structural diversity of polyketide natural products can be increased.

    • Tom Bretschneider
    • Joel B. Heim
    • Christian Hertweck
    Research
    Nature
    Volume: 502, P: 124-128

  • In this work, ‘hyperpolarized water’ produced by cryogenic dynamic nuclear polarization is used to boost signal intensities in NMR of proteins and nucleic acids. This allows NMR at lower concentrations and detection of folding intermediates.

    • Christian Hilty
    • Dennis Kurzbach
    • Lucio Frydman
    Protocols
    Nature Protocols
    Volume: 17, P: 1621-1657