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Showing 1–3 of 3 results
Advanced filters: Author: Christian Pichlo Clear advanced filters

  • ZUFSP-type enzymes cleave ubiquitin chains in a linkage-specific fashion, but members from different organisms have different specificities. Using an inter-kingdom comparison of activities and structures, the authors identify the domains responsible for this discrepancy.

    • Thomas Hermanns
    • Christian Pichlo
    • Kay Hofmann
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Mutations in the hexosamine pathway key enzyme glutamine fructose-6-phosphate amidotransferase (GFAT-1) improve protein quality control and extend C. elegans lifespan. Here the authors present the crystal structures of full-length human GFAT-1 alone and with bound ligands and perform activity assays, which show that gain-of-function in the longevity-associated G451E variant is caused by a loss of feedback regulation.

    • Sabine Ruegenberg
    • Moritz Horn
    • Martin S. Denzel
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Deubiquitinating enzymes (DUBs) are essential to modulate ubiquitin signaling. While known DUBs can be grouped into six families, the authors here present biochemical and structural evidence for a seventh DUB family, defining determinants of substrate specificity for two representative enzymes.

    • Thomas Hermanns
    • Christian Pichlo
    • Kay Hofmann
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13