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Showing 1–2 of 2 results
Advanced filters: Author: Christiane Koppe Clear advanced filters

  • The involvement of cell death pathways in the early stage of pancreatic ductal adenocarcinoma (PDAC) development, especially KRAS-dependent acinar-to-ductal metaplasia (ADM), remains to be investigated. Here, the authors find that TAK1 mediates cell survival during ADM transdifferentiation through suppression of apoptosis and necroptosis, which could be targeted for prevention and treatment of PDAC.

    • Anne T. Schneider
    • Christiane Koppe
    • Tom Luedde
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • The kinase RIPK3 initiates necroptosis, which has been reported to promote inflammation in various pathological conditions. Here, the authors show that genetic ablation of Ripk3results in adipocyte apoptosis and white adipose tissue inflammation in obese mice, which promotes glucose intolerance.

    • Jérémie Gautheron
    • Mihael Vucur
    • Tom Luedde
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-16