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Showing 1–2 of 2 results
Advanced filters: Author: Christianne Groeneveldt Clear advanced filters

  • The dense desmoplastic stroma and insufficient infiltrating T cells limit effective immunotherapy in pancreatic ductal adenocarcinoma (PDAC). The authors here administer an autologous dendritic cell (DC) vaccine (MesoPher) with an agonistic CD40-specific antibody (mitazalimab) to patients with metastatic PDAC after (m)FOLFIRINOX standard-of-care treatment and find MesoPher/mitazalimab combination therapy is safe and tolerable, accompanied with enhanced systemic and local immune responses.

    • Songul Kucukcelebi
    • Freek R. van ‘t Land
    • Casper H. J. van Eijck
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • CD3 bispecific antibodies (bsAbs) have demonstrated promising clinical responses in hematological malignancies but clinical benefit in solid tumors has been limited. Here the authors report that pre-treatment vaccination promotes the infiltration of tumor-(un)related effector CD8 T cells, improving the efficacy of CD3 bsAbs in solid tumors.

    • Jim Middelburg
    • Marjolein Sluijter
    • Thorbald van Hall
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15