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Showing 1–2 of 2 results
Advanced filters: Author: Christina Hetzmannseder Clear advanced filters

  • The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large subunit. Here the authors report the structure of Drg1 in complex with its specific inhibitor diazaborine and provide insight into the mechanism of inhibition and specificity of this class of inhibitors.

    • Michael Prattes
    • Irina Grishkovskaya
    • Helmut Bergler
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • The AAA-ATPase Drg1 assembles at the pre-60S ribosomal particle to release the ribosomal maturation factor Rlp24. Here, single-particle cryo-EM and 3D variability analysis dynamically visualize Rlp24 release by hand-over-hand substrate translocation.

    • Michael Prattes
    • Irina Grishkovskaya
    • Helmut Bergler
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 942-953