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Showing 1–2 of 2 results
Advanced filters: Author: Christine E. Ronayne Clear advanced filters

  • Patterson, Firulyova, et al. report that TREM2 is a key regulator of foamy macrophage differentiation. Myeloid-specific deletion of Trem2 caused increased macrophage susceptibility to cholesterol-mediated toxicity and cell death and significantly attenuated atherosclerotic plaque progression in mice.

    • Michael T. Patterson
    • Maria M. Firulyova
    • Jesse W. Williams
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 2, P: 1015-1031

  • Marking of recently activated T cells may help further our understanding of immunity against Mycobacterium tuberculosis (Mtb). Here the authors use Nur77-GFP reporter mice infected with Mtb and systems data approaches to implicate OX40 as a marker for recently activated, functionally and transcriptome-wise distinct CD4 T cells, and as a potential target for immunotherapy.

    • Abigail R. Gress
    • Christine E. Ronayne
    • Tyler D. Bold
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16