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Showing 1–8 of 8 results
Advanced filters: Author: Christine Grienberger Clear advanced filters

  • The amyloid-β-peptide is pivotal to the pathology of Alzheimer's disease, but its mechanism of action remains uncertain. This study utilizesin vivotwo-photon calcium imaging to investigate the effects of this peptide on single cortical neurons of the visual cortex in a mouse model of Alzheimer's disease.

    • Christine Grienberger
    • Nathalie L. Rochefort
    • Arthur Konnerth
    ResearchOpen Access
    Nature Communications
    Volume: 3, P: 1-10

  • Two-photon calcium imaging is a technique used for recording neuronal activity in the brain. In this Primer, Grienberger et al. outline the experimental design and execution of two-photon calcium imaging, providing examples of ideal preparations and how data are analysed.

    • Christine Grienberger
    • Andrea Giovannucci
    • Carlos Portera-Cailliau
    Reviews
    Nature Reviews Methods Primers
    Volume: 2, P: 1-23

  • The authors investigate the role of inhibition in shaping spatial selectivity of CA1 place cells. Combining whole-cell recordings, optogenetics and computational modeling, they demonstrate that inhibition enhances both rate and temporal coding of space by counteracting noise from broad out-of-field excitation.

    • Christine Grienberger
    • Aaron D Milstein
    • Jeffrey C Magee
    Research
    Nature Neuroscience
    Volume: 20, P: 417-426

  • Immunotherapy with antibodies targeting the amyloid-β peptide has yet to show any cognitive benefit in Alzheimer's disease patients in clinical trials. In vivo two-photon imaging in mouse models of Alzheimer's disease now reveals that these antibodies do not alleviate neuronal dysfunction and can even worsen it.

    • Marc Aurel Busche
    • Christine Grienberger
    • Arthur Konnerth
    Research
    Nature Neuroscience
    Volume: 18, P: 1725-1727

  • β-amyloid (Aβ)-dependent neuronal hyperactivity is an early marker of Alzheimer’s Disease (AD). Here, the authors report that scavenging Aβ monomers by an Aβ-binding anticalin protein blocks the formation of Aβ oligomers and prevents hyperactivity in AD mice.

    • Benedikt Zott
    • Lea Nästle
    • Arthur Konnerth
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Analysis of the activity of CA1 cells in mice performing a learning task shows that the entorhinal cortex signals behavioural timescale synaptic plasticity to generate learning-related changes in the hippocampus.

    • Christine Grienberger
    • Jeffrey C. Magee
    ResearchOpen Access
    Nature
    Volume: 611, P: 554-562

  • The authors found that dendritic plateau potentials, resulting from the conjunction of EC3 and CA3 inputs, positively modulate existing place fields and induce novel place field formation in CA1 pyramidal neurons. Such a canonical circuit operation may support the formation of spatial maps in the hippocampus and the acquisition of feature selectivity elsewhere in cortex.

    • Katie C Bittner
    • Christine Grienberger
    • Jeffrey C Magee
    Research
    Nature Neuroscience
    Volume: 18, P: 1133-1142