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Showing 1–5 of 5 results
Advanced filters: Author: Christine Hilcenko Clear advanced filters

  • Shwachman-Diamond syndrome (SDS) is a leukemia predisposition disorder that is caused by defective release of eIF6 during ribosome assembly. Here the authors show that acquired somatic EIF6 mutations are frequent in the hematopoietic cells from individuals with SDS and provide a selective advantage over non-modified cells.

    • Shengjiang Tan
    • Laëtitia Kermasson
    • Patrick Revy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Agarwal et al. show that vesicle-associated membrane protein 2 interacts with and regulates α-synuclein biomolecular condensation, affecting α-synuclein function, which may prevent pathological amyloid aggregation.

    • Aishwarya Agarwal
    • Aswathy Chandran
    • Janin Lautenschläger
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 1296-1308

  • Jaako et al. discover a conserved tier of translational control that dynamically couples ribosome assembly and recycling. This mechanism is corrupted in an inherited bone marrow failure disorder associated with an increased risk of blood cancer.

    • Pekka Jaako
    • Alexandre Faille
    • Alan J. Warren
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • During eukaryotic ribosome biogenesis, the nascent 60S subunit is activated by SBDS and GTPase EFL1. Cryo-EM and mutational analyses reveal how SBDS–EFL1 evicts antiassociation factor eIF6 from 60S and explain the effects of disease-related SBDS mutations.

    • Félix Weis
    • Emmanuel Giudice
    • Alan J Warren
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 914-919