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Showing 1–6 of 6 results
Advanced filters: Author: Christine S. Moravec Clear advanced filters

  • Wang, Tang and colleagues develop the low-signal signed iterative random forest pipeline to investigate epistasis in the genetic control of cardiac hypertrophy, identifying epistatic variants near CCDC141, IGF1R, TTN and TNKS loci, and show that hypertrophy in induced pluripotent stem cell-derived cardiomyocytes is nonadditively influenced by interactions among CCDC141, TTN and IGF1R.

    • Qianru Wang
    • Tiffany M. Tang
    • Euan A. Ashley
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 4, P: 740-760

  • The genetic and pathogenetic basis of heart failure is incompletely understood. Here, the authors present a high-fidelity tissue collection from rapidly preserved failing and non-failing control hearts which are used for eQTL mapping and network analysis, resulting in the prioritization of PPP1R3A as a heart failure gene.

    • Pablo Cordero
    • Victoria N. Parikh
    • Euan A. Ashley
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Allosteric modulation is crucial in metabolic regulation but unexplored in gut microbehost interactions. Here the authors show gut microbe-derived phenylacetylglutamine acts as a negative allosteric modulator of β2-adrenergic receptors, impacting heart function.

    • Prasenjit Prasad Saha
    • Valentin Gogonea
    • Stanley L. Hazen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Christopher Newton-Cheh and colleagues report genome-wide association analyses for QT interval, an electrocardiographic measure reflecting myocardial repolarization, in 100,000 individuals. They identify 35 loci associated with QT interval and highlight a role for calcium regulation in myocardial repolarization.

    • Dan E Arking
    • Sara L Pulit
    • Christopher Newton-Cheh
    Research
    Nature Genetics
    Volume: 46, P: 826-836

  • Decreased expression of BAG3 in the heart is associated with contractile dysfunction and heart failure. Here the authors show that this is due to decreased BAG3-dependent sarcomere protein turnover, which impairs mechanical function, and that sarcomere force-generating capacity is restored with BAG3 gene therapy.

    • Thomas G. Martin
    • Valerie D. Myers
    • Jonathan A. Kirk
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Das et al. present a novel Bayesian approach called expression Quantitative Trait enhancer Loci (eQTeL), which effectively integrates genetic and epigenetic information to identify combination of regulatory genomic variants underlying expression variance. Using various functional data, the authors show the variants identified by eQTeL are likely to be causal.

    • Avinash Das
    • Michael Morley
    • Sridhar Hannenhalli
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11