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Showing 1–3 of 3 results
Advanced filters: Author: Christoffel Dinant Clear advanced filters

  • Cancer stem cells can evade treatment. Here, the authors perform an in vitro screen to identify proteins that are involved in protecting glioma cancer stem cells from therapy and find that SPT6 increases BRCA1 expression and drives error-free DNA repair, thereby ensuring the survival of the cells.

    • Elisabeth Anne Adanma Obara
    • Diana Aguilar-Morante
    • Petra Hamerlik
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • A DNA double strand break can be repaired through either the non-homologous end-joining or the homologous recombination pathways. Here the authors conduct a genome-wide screen and identify a role for CCAR2 in pathway choice by regulating DNA end resection by CtIP.

    • Ana López-Saavedra
    • Daniel Gómez-Cabello
    • Pablo Huertas
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14