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Showing 1–3 of 3 results
Advanced filters: Author: Christoph Brenker Clear advanced filters

  • Progesterone stimulates an increase in Ca2+ levels in human sperm, but the underlying signalling mechanism is poorly understood. Two studies now show that progesterone activates the sperm-specific, pH-sensitive CatSper calcium channel, leading to a rapid influx of Ca2+ ions into the spermatozoa. These results should help to define the physiological role of progesterone and CatSper in sperm, and could lead to the development of new classes of non-hormonal contraceptives.

    • Timo Strünker
    • Normann Goodwin
    • U. Benjamin Kaupp
    Research
    Nature
    Volume: 471, P: 382-386

  • Sperm use external cues to find the egg using ill-defined principles. Here the authors use holographic microscopy and optochemical tools to study sperm swimming in light-sculpted chemical 3D landscapes; they show that sperm translate the temporal stimulation pattern into multiple swimming behaviours to orient deterministically in a gradient.

    • Jan F. Jikeli
    • Luis Alvarez
    • U. Benjamin Kaupp
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Various endogenous and pathogen-derived stimuli trigger the assembly of cytosolic multimolecular 'speck' platforms coordinated by the adapter ASC. Latz and colleagues demonstrate that ASC specks have extracellular functions that can prolong inflammation.

    • Bernardo S Franklin
    • Lukas Bossaller
    • Eicke Latz
    Research
    Nature Immunology
    Volume: 15, P: 727-737