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Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro

Charlotte M. Flynn
Yvonne Garbers
Christoph Garbers
ResearchOpen Access10 Dec 2020
Scientific Reports

Volume: 10, P: 1-13
Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment

Inflammation can be induced by obesity, and has been linked with onset of colorectal cancer (CAC). Here the authors show in mouse models that obesity-induced interleukin-6 alters macrophage function to enhance CCL-20/CCR-6-mediated recruitment of B cells and γδ T cells, thereby promoting gut inflammation and CAC progression.

Claudia M. Wunderlich
P. Justus Ackermann
F. Thomas Wunderlich
ResearchOpen Access25 Apr 2018
Nature Communications

Volume: 9, P: 1-16
Correction: Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T_H17 cells

Sylvia Heink
Nir Yogev
Thomas Korn
Amendments and Corrections22 Mar 2017
Nature Immunology

Volume: 18, P: 474
Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling

Charlotte M. Flynn
Yvonne Garbers
Christoph Garbers
ResearchOpen Access13 May 2019
Scientific Reports

Volume: 9, P: 1-11
Treatment of type 2 diabetes with the designer cytokine IC7Fc

The chimeric cytokine IC7Fc combines the beneficial effects of the cytokines IL-6 and CNTF on weight loss and metabolism in mice, with no obvious side effects in mice and non-human primates.

Maria Findeisen
Tamara L. Allen
Mark A. Febbraio
Research25 Sept 2019
Nature

Volume: 574, P: 63-68
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T_H17 cells

Korn and colleagues report that Sirpα⁺ dendritic cells trans-present the cytokine IL-6 to T cells through a process that requires its receptor IL-6Rα bound to dendritic cells and that trans-presentation is needed to generate pathogenic cells of the T_H17 subset of helper T cells in vivo.

Sylvia Heink
Nir Yogev
Thomas Korn
Research28 Nov 2016
Nature Immunology

Volume: 18, P: 74-85
The interleukin-11 receptor variant p.W307R results in craniosynostosis in humans

Ilyas Ahmad
Juliane Lokau
Christoph Garbers
ResearchOpen Access18 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes

Shruti Chopra
Janine Siegl
Katinka Döhner
ResearchOpen Access03 Jun 2025
Scientific Reports

Volume: 15, P: 1-15
Ionic mitigation of CD4⁺ T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc

Anna Krone
Yan Fu
Sascha Kahlfuss
ResearchOpen Access04 Feb 2022
Scientific Reports

Volume: 12, P: 1-14
Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling

Philipp Arnold
Inga Boll
Christoph Becker-Pauly
ResearchOpen Access09 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
Interleukin-6: designing specific therapeutics for a complex cytokine

Dysregulation of IL-6 signalling is associated with inflammatory and lymphoproliferative disorders, and several classes of therapeutics have been developed that target components of the IL-6 signalling pathway. This Review describes the progress made in recent years in inhibiting IL-6-signalling and analyses the advantages and disadvantages of these approaches.

Christoph Garbers
Sylvia Heink
Stefan Rose-John
Reviews04 May 2018
Nature Reviews Drug Discovery

Volume: 17, P: 395-412
Targeting IL-6 trans-signalling: past, present and future prospects

This Review details the discovery of the interleukin-6 (IL-6) trans-signalling pathway and the subsequent development of biologics that specifically inhibit this pathway. Emerging evidence suggests that specifically targeting IL-6 trans-signalling can reduce pathological disease-promoting activities of IL-6 without blocking the protective actions of IL-6 in infection and tissue repair.

Stefan Rose-John
Brendan J. Jenkins
Jürgen Scheller
Reviews17 Apr 2023
Nature Reviews Immunology

Volume: 23, P: 666-681
Erratum: Control of ADAM17 activity by regulation of its cellular localisation

Inken Lorenzen
Juliane Lokau
Stefan Düsterhöft
Amendments and CorrectionsOpen Access21 Nov 2016
Scientific Reports

Volume: 6, P: 1-2
New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology

In this Review, the authors describe the biology of IL-6 family cytokines relevant to metabolism, liver disease and gastrointestinal disease, and discuss the potential of IL-6 family members as therapeutic agents in these areas.

Maria D. Giraldez
David Carneros
Matilde Bustos
Reviews01 Jul 2021
Nature Reviews Gastroenterology & Hepatology

Volume: 18, P: 787-803
Transgenic inhibition of interleukin-6 trans-signaling does not prevent skeletal pathologies in mucolipidosis type II mice

Lena Marie Westermann
Anke Baranowsky
Sandra Pohl
ResearchOpen Access11 Feb 2021
Scientific Reports

Volume: 11, P: 1-10
Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17

Steffen Riethmueller
Johanna C. Ehlers
Christoph Garbers
ResearchOpen Access06 May 2016
Scientific Reports

Volume: 6, P: 1-14
Control of ADAM17 activity by regulation of its cellular localisation

Inken Lorenzen
Juliane Lokau
Stefan Düsterhöft
ResearchOpen Access12 Oct 2016
Scientific Reports

Volume: 6, P: 1-15

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Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro

Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment

Correction: Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T_H17 cells

Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling

Treatment of type 2 diabetes with the designer cytokine IC7Fc

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T_H17 cells

The interleukin-11 receptor variant p.W307R results in craniosynostosis in humans

RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes

Ionic mitigation of CD4⁺ T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling

Interleukin-6: designing specific therapeutics for a complex cytokine

Targeting IL-6 trans-signalling: past, present and future prospects

Erratum: Control of ADAM17 activity by regulation of its cellular localisation

New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology

Transgenic inhibition of interleukin-6 trans-signaling does not prevent skeletal pathologies in mucolipidosis type II mice

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17

Control of ADAM17 activity by regulation of its cellular localisation

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