Nature Search

Once upon a spine: setting striatal dopamine

The prefrontal cortex is known to influence dopamine release in the striatum–but how? New data in mice suggest that cortical spine density affects striatal dopamine release via monosynaptic control of dopamine neurons, tracing a chain of events from spine loss to antipsychotic-responsive psychomotor agitation.

Christoph Kellendonk
Joshua A Gordon
News & Views26 May 2015
Nature Neuroscience

Volume: 18, P: 788-789
Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function

Benoit et al. show that inhibition of the thalamus during adolescence leads to long-lasting changes in prefrontal cortex function and behavior, demonstrating the importance of adolescent thalamic activity for prefrontal circuit maturation.

Laura J. Benoit
Emma S. Holt
Christoph Kellendonk
Research19 May 2022
Nature Neuroscience

Volume: 25, P: 714-725
Publisher Correction: Thalamic projections sustain prefrontal activity during working memory maintenance

Scott S Bolkan
Joseph M Stujenske
Christoph Kellendonk
Amendments and Corrections31 May 2018
Nature Neuroscience

Volume: 21, P: 1138
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

François Tronche
Christoph Kellendonk
Günther Schütz
Research01 Sept 1999
Nature Genetics

Volume: 23, P: 99-103
Thalamic projections sustain prefrontal activity during working memory maintenance

Using pathway-specific optogenetic inhibition, the authors demonstrate that projections from the mediodorsal thalamus to prefrontal cortex support the maintenance of working memory, while prefrontal–thalamic projections support subsequent choice selection. Thalamo–prefrontal projections have a circuit-specific role in sustaining prefrontal delay-period activity, a neuronal signature required for successful task performance.

Scott S Bolkan
Joseph M Stujenske
Christoph Kellendonk
Research03 May 2017
Nature Neuroscience

Volume: 20, P: 987-996
A non-canonical striatopallidal Go pathway that supports motor control

The basal ganglia direct and indirect pathways are classically described as anatomically segregated and functionally opposing. Here the authors describe a non-canonical direct pathway made of axon collaterals to the globus pallidus that promotes motor action.

Marie A. Labouesse
Arturo Torres-Herraez
Christoph Kellendonk
ResearchOpen Access23 Oct 2023
Nature Communications

Volume: 14, P: 1-20
Reset of hippocampal–prefrontal circuitry facilitates learning

Exposure to a novel experience can ‘reset’ connections between the hippocampus and prefrontal cortex in mice, allowing them to overcome an existing learned behaviour and to replace it with a new one.

Alan J. Park
Alexander Z. Harris
Joshua A. Gordon
Research24 Feb 2021
Nature

Volume: 591, P: 615-619
Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder

Mutations in CNTNAP2 have been associated with a syndromic form of Autism Spectrum Disorder. Here the authors show that forebrain organoids generated from induced pluripotent stem cells of patients with a syndromic form of ASD with a homozygous truncating mutation in CNTNAP2 displayed an increase in volume and total cell number, which is driven by abnormal cellular proliferation and neurogenesis.

Job O. de Jong
Ceyda Llapashtica
Sander Markx
ResearchOpen Access01 Sept 2021
Nature Communications

Volume: 12, P: 1-14
Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum

Striatal dopaminoceptive neurons are molecularly and functionally heterogeneous. Here, the authors provide the translatome of D2R striatal neurons and identified hundreds of region specific molecular markers as well as testing their resource to shed light into function.

Emma Puighermanal
Laia Castell
Emmanuel Valjent
ResearchOpen Access23 Apr 2020
Nature Communications

Volume: 11, P: 1-15
Disruption of CREB function in brain leads to neurodegeneration

Theo Mantamadiotis
Thomas Lemberger
Günther Schütz
Research22 Apr 2002
Nature Genetics

Volume: 31, P: 47-54
Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice

Brain mitochondria play crucial roles that influence cognition, yet their diversity is often overlooked. This study in mice identifies distinct mitochondrial phenotypes distributed as large-scale networks, accounting for a large portion of animal-to-animal behavioural variation.

Ayelet M. Rosenberg
Manish Saggar
Martin Picard
ResearchOpen Access10 Aug 2023
Nature Communications

Volume: 14, P: 1-19
Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum

Dopamine D2 receptor activity in the nucleus accumbens is associated with regulation of motivated responding. Here the authors show that overexpression of D2 receptors specifically in ventral striatal projection neurons leads to an increase in the willingness to work by reducing inhibitory transmission to ventral pallidal neurons.

Eduardo F. Gallo
Jozsef Meszaros
Christoph Kellendonk
ResearchOpen Access14 Mar 2018
Nature Communications

Volume: 9, P: 1-13
How changes in dopamine D2 receptor levels alter striatal circuit function and motivation

Eleanor H. Simpson
Eduardo F. Gallo
Christoph Kellendonk
Reviews12 Aug 2021
Molecular Psychiatry

Volume: 27, P: 436-444
Inhibition of striatal indirect pathway during second postnatal week leads to long-lasting deficits in motivated behavior

Pedro R. Olivetti
Arturo Torres-Herraez
Christoph Kellendonk
Research26 Sept 2024
Neuropsychopharmacology

Volume: 50, P: 651-661
Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning

Eduardo F. Gallo
Julia Greenwald
Christoph Kellendonk
Research17 Nov 2021
Molecular Psychiatry

Volume: 27, P: 1502-1514
New roles for dopamine D₂ and D₃ receptors in pancreatic beta cell insulin secretion

Zachary J. Farino
Travis J. Morgenstern
Zachary Freyberg
Research09 Jan 2019
Molecular Psychiatry

Volume: 25, P: 2070-2085
Dopamine D2 receptor overexpression in the nucleus accumbens core induces robust weight loss during scheduled fasting selectively in female mice

Amanda C. Welch
Jie Zhang
Stephanie C. Dulawa
Research20 Dec 2019
Molecular Psychiatry

Volume: 26, P: 3765-3777
Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation

Prashant Donthamsetti
Eduardo F. Gallo
Jonathan A. Javitch
Research17 Aug 2018
Molecular Psychiatry

Volume: 25, P: 2086-2100
An ace in the hole? Opportunities and limits of using mice to understand schizophrenia neurobiology

Joseph M. Villarin
Christoph Kellendonk
Reviews22 May 2025
Molecular Psychiatry

Volume: 30, P: 4384-4398
Upregulation of Dopamine D2 Receptors in the Nucleus Accumbens Indirect Pathway Increases Locomotion but Does Not Reduce Alcohol Consumption

Eduardo F Gallo
Michael C Salling
Christoph Kellendonk
Research12 Jan 2015
Neuropsychopharmacology

Volume: 40, P: 1609-1618

Search

Once upon a spine: setting striatal dopamine

Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function

Publisher Correction: Thalamic projections sustain prefrontal activity during working memory maintenance

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

Thalamic projections sustain prefrontal activity during working memory maintenance

A non-canonical striatopallidal Go pathway that supports motor control

Reset of hippocampal–prefrontal circuitry facilitates learning

Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder

Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum

Disruption of CREB function in brain leads to neurodegeneration

Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice

Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum

How changes in dopamine D2 receptor levels alter striatal circuit function and motivation

Inhibition of striatal indirect pathway during second postnatal week leads to long-lasting deficits in motivated behavior

Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning

New roles for dopamine D₂ and D₃ receptors in pancreatic beta cell insulin secretion

Dopamine D2 receptor overexpression in the nucleus accumbens core induces robust weight loss during scheduled fasting selectively in female mice

Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation

An ace in the hole? Opportunities and limits of using mice to understand schizophrenia neurobiology

Upregulation of Dopamine D2 Receptors in the Nucleus Accumbens Indirect Pathway Increases Locomotion but Does Not Reduce Alcohol Consumption

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