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Showing 1–6 of 6 results
Advanced filters: Author: Christoph Lepper Clear advanced filters

  • Skeletal muscle cells contain hundreds of nuclei, but can also add new nuclei in response to various stimuli. Here, the authors perform lineage tracing on the newly fused nuclei showing that these exhibit unique transcriptional states depending on the stimulus.

    • Chengyi Sun
    • Casey O. Swoboda
    • Douglas P. Millay
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • After development, adult skeletal muscle retains the capacity to regenerate by activating muscle stem cells. Here the authors demonstrate that the glycosylphosphatidylinositol-anchored membrane protein GAS1, which is induced in muscle stem cells with age, suppresses muscle regenerative capacity but can be inhibited by glial cell line-derived neurotrophic factor (GDNF).

    • Liangji Li
    • Michelle Rozo
    • Chen-Ming Fan
    Research
    Nature Metabolism
    Volume: 1, P: 985-995

  • The myogenic determinant Pax7 is thought to have a critical role in adult muscle stem cells (satellite cells), but a formal demonstration has been lacking in vivo. Here it is shown that, unexpectedly, when Pax7 is inactivated in adult mice, mutant satellite cells are not compromised in muscle regeneration. Multiple time points of gene inactivation reveal that Pax7 is only required up to the juvenile period, indicating an age-dependent change in the genetic requirement for muscle stem cells.

    • Christoph Lepper
    • Simon J. Conway
    • Chen-Ming Fan
    Research
    Nature
    Volume: 460, P: 627-631

  • This study highlights the role of YTHDF2, a protein that recognizes m6A-modified RNA, in determining muscle size. The authors show a post-transcriptional mechanism regulating muscle catabolism and growth, prompting interest to address muscle wasting.

    • Christopher J. Gilbert
    • Charles P. Rabolli
    • Federica Accornero
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Satellite cells can differentiate both into myocytes and brown adipocytes. Here, the authors show that the histone demethylase Lsd1 prevents adipogenic differentiation of satellite cells by repressing expression of Glis1, and that its ablation changes satellite cell fate towards brown adipocytes and delays muscle regeneration in mice.

    • Milica Tosic
    • Anita Allen
    • Roland Schüle
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14