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Advanced filters: Author: Christoph Schlepphorst Clear advanced filters
  • Despite their huge potential in medicinal chemistry, current approaches for the synthesis of fluorinated piperidines are often impractical. A straightforward process for the rhodium-catalysed dearomatization–hydrogenation of fluoropyridines has now been described. This strategy enables the highly diastereoselective formation of a variety of all-cis-(multi)fluorinated piperidines and the study of their conformational behaviour.

    • Zackaria Nairoukh
    • Marco Wollenburg
    • Frank Glorius
    Research
    Nature Chemistry
    Volume: 11, P: 264-270