Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–7 of 7 results
Advanced filters: Author: Christophe Guilluy Clear advanced filters

  • Angiotensin II contracts blood vessels and has been implicated as a causative factor in hypertension. Christophe Guilluy et al. now demonstrate that the guanine exchange factor Arghef1 is required for the hypertensive effects of angiotensin II in mice, and describe a new signaling pathway by which angiotensin II triggers Jak2-dependent activation of Arghef1 to cause smooth muscle cell contraction (pages 165–166).

    • Christophe Guilluy
    • Jérémy Brégeon
    • Gervaise Loirand
    Research
    Nature Medicine
    Volume: 16, P: 183-190

  • While integrin-based adhesions are thought to underlie many aspects of cell response to localized tension, another matrix receptor, syndecan-4, has now been shown to act as a mechanosensor, which triggers cell-wide integrin activation and adhesion reinforcement.

    • Christophe Guilluy
    • Monika E. Dolega
    News & Views
    Nature Materials
    Volume: 19, P: 587-588

  • Mechanical force causes stiffening, or reinforcement, of integrin-based cellular adhesions. This reinforcement is shown to be mediated by the recruitment of the LARG and GEF-H1 guanine nucleotide exchange factors, which activate distinct signalling pathways in response to integrin stimulation.

    • Christophe Guilluy
    • Vinay Swaminathan
    • Keith Burridge
    Research
    Nature Cell Biology
    Volume: 13, P: 722-727

  • Endothelial cells at the inner surface of blood vessels are exposed to mechanical forces as a result of blood flow. Here the authors show that the interaction of extracellular matrix proteins with adhesion molecules on the endothelial cell surface determines cellular stiffness and sensitivity to mechanical forces.

    • Caitlin Collins
    • Lukas D. Osborne
    • Ellie Tzima
    Research
    Nature Communications
    Volume: 5, P: 1-12

  • Rho guanine nucleotide dissociation inhibitors (RhoGDIs) bind to inactive Rho GTPases in the cytosol, but their function remains unclear. Several Rho GTPases are now shown to compete for RhoGDI binding and this is crucial for regulating Rho GTPase turnover and activation.

    • Etienne Boulter
    • Rafael Garcia-Mata
    • Keith Burridge
    Research
    Nature Cell Biology
    Volume: 12, P: 477-483