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Showing 1–3 of 3 results
Advanced filters: Author: Christophe L. M. J. Verlinde Clear advanced filters

  • Iterative protein structure-based ligand design has led to a ‘selective’ inhibitor of human non-pancreatic secretory phospholipase A2 which provides a new tool for probing metabolic pathways and may lead to a useful drug.

    • Christophe L.M.J. Verlinde
    • Bauke W. Dijkstra
    News & Views
    Nature Structural Biology
    Volume: 2, P: 429-432

  • A family of calcium-dependent protein kinases (CDPK) is present in apicomplexan parasites but not in animals, indicating their potential as targets for anti-parasitic drugs. Structural and functional studies on Toxoplasma gondii CDPK1 now reveal that this kinase is sensitive to a class of drugs called bumped kinase inhibitors, which can inhibit the parasite's growth and host cell invasion.

    • Kayode K Ojo
    • Eric T Larson
    • Wesley C Van Voorhis
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 602-607

  • The wealth of genomic data for pathogens that cause tropical diseases hold considerable promise for the discovery of novel drugs. An international consortium describes how the TDR Targets database integrates this data with related biochemical and pharmacological data to facilitate the identification and prioritization of drug targets.

    • Fernán Agüero
    • Bissan Al-Lazikani
    • Christophe L. M. J. Verlinde
    Reviews
    Nature Reviews Drug Discovery
    Volume: 7, P: 900-907