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Showing 1–10 of 10 results
Advanced filters: Author: Christopher C. Ebmeier Clear advanced filters

  • Gene activation may involve the formation of a DNA loop that connects enhancer-bound transcription factors with the transcription apparatus at the core promoter. But this process is not well understood. Here, two proteins, mediator and cohesin, are shown to connect the enhancers and core promoters of active genes in embryonic stem cells. These proteins seem to generate cell-type-specific DNA loops linked to the gene expression program of each cell.

    • Michael H. Kagey
    • Jamie J. Newman
    • Richard A. Young
    Research
    Nature
    Volume: 467, P: 430-435

  • Here the authors report that the Taf2 and Taf14 subunits of the yeast TFIID complex interact and mediate binding to chromatin. Binding of Taf2 to Taf14 promotes a conformational rearrangement in Taf14, resulting in a release of the linker region for the engagement with the nucleosome and their association with DNA is essential for transcriptional regulation.

    • Brianna J. Klein
    • Jordan T. Feigerle
    • Tatiana G. Kutateladze
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Human acetyltransferases MOZ and MORF mediate development programs and are dysregulated in diseases. Here the authors identified two winged helix (WH) domains in MORF/MOZ and characterized their DNA binding functions, including targeting of CpG by WH1.

    • Dustin C. Becht
    • Brianna J. Klein
    • Tatiana G. Kutateladze
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • The histone acetyltransferase p300 mostly localizes to active chromatin; however, some repressed genes marked with H3K27me3 are also bound by p300. Here the authors show p300 is capable of phase separation, which relies on its catalytic core, and that p300 catalytic activity is decreased in phase-separated droplets that co-localize with H3K27me3-marked chromatin.

    • Yi Zhang
    • Kyle Brown
    • Tatiana G. Kutateladze
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • CDK8 is a kinase found in some Mediator complexes and has been implicated in oncogenesis. Now it is shown to be a positive regulator of transcription elongation at immediate early serum response genes, regulating recruitment of elongation factors including P-TEFb.

    • Aaron J Donner
    • Christopher C Ebmeier
    • Joaquín M Espinosa
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 194-201

  • The protein TRIM28 is identified as a factor that modulates RNA polymerase II pausing and transcriptional elongation at a large number of mammalian genes. This function is regulated by transcription-coupled phosphorylation of TRIM28 at Ser824.

    • Heeyoun Bunch
    • Xiaofeng Zheng
    • Stuart K Calderwood
    Research
    Nature Structural & Molecular Biology
    Volume: 21, P: 876-883

  • A small-molecule inhibitor of the Mediator-associated kinases CDK8 and CDK19 inhibits growth of acute myeloid leukaemia (AML) cells and induces upregulation of super-enhancer-associated genes with tumour suppressor and lineage-controlling functions; Mediator kinase inhibition therefore represents a promising therapeutic approach for AML.

    • Henry E. Pelish
    • Brian B. Liau
    • Matthew D. Shair
    Research
    Nature
    Volume: 526, P: 273-276