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npj Vaccines (1)

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Advanced filters: Author: Christopher C. Stobart Clear advanced filters

A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation

Development of a safe and efficacious vaccine for respiratory syncytial virus (RSV) has been challenging. Here the authors generate a live-attenuated RSV vaccine that shows increased thermostability and immunogenicity, and protects cotton rats from RSV challenge.

Christopher C. Stobart
Christina A. Rostad
Martin L. Moore
ResearchOpen Access21 Dec 2016
Nature Communications

Volume: 7, P: 1-12
Assembly of respiratory syncytial virus matrix protein lattice and its coordination with fusion glycoprotein trimers

Here the authors use cryo-electron tomography and sub-tomogram averaging to determine the molecular organization of RSV. The structures show that the matrix (M) protein packs as a helical-like lattice and the F glycoprotein is present as anti-parallel pairs of trimers and coordinates with the M lattice.

Bryan S. Sibert
Joseph Y. Kim
Elizabeth R. Wright
ResearchOpen Access14 Jul 2024
Nature Communications

Volume: 15, P: 1-13
Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2

Mariana F. Tioni
Robert Jordan
Roderick S. Tang
ResearchOpen Access29 Jul 2022
npj Vaccines

Volume: 7, P: 1-13

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