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Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage

Here, the authors provide molecular insight into the remarkable ability of Tardigrades to withstand high levels of radiation by demonstrating that their Dsup protein interacts with multiple surfaces of the nucleosome to protect the genome from oxidative DNA damage.

Rhiannon R. Aguilar
Laiba F. Khan
Jessica K. Tyler
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-17
NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers

A highly potent and selective small-molecule catalytic inhibitor of the protein lysine methyltransferase NSD2 shows therapeutic efficacy in preclinical models of KRAS-driven pancreatic cancer and lung cancer.

Jinho Jeong
Simone Hausmann
Or Gozani
Research06 Aug 2025
Nature

Volume: 649, P: 205-215
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture

Mutations in histone H1 induce the remodelling of chromatin architecture to a more relaxed state, which leads to malignant transformation through changes in histone modifications and the expression of stem cell genes.

Nevin Yusufova
Andreas Kloetgen
Ari M. Melnick
Research09 Dec 2020
Nature

Volume: 589, P: 299-305
U1 snRNP telescripting regulates a size–function-stratified human genome

Genome-wide analyses of the effects of U1 snRNP inhibition in human cells shows that telescripting suppresses premature cleavage and polyadenylation in long introns to sustain expression of large genes important for cell cycle and development.

Jung-Min Oh
Chao Di
Gideon Dreyfuss
Research02 Oct 2017
Nature Structural & Molecular Biology

Volume: 24, P: 993-999
Author Correction: Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

Praveen R. Juvvadi
David Fox III
William J. Steinbach
Amendments and CorrectionsOpen Access03 Jul 2025
Nature Communications

Volume: 16, P: 1-3
Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

FK506 is a potential antifungal compound that inhibits calcineurin, but it also has immunosuppressive activity. Here, Juvvadi et al. report the structure of FK506 in complex with the FK506-binding protein FKPB12 and calcineurin, and design a less immunosuppresive FK506 analog with antifungal activity in mice.

Praveen R. Juvvadi
David Fox III
William J. Steinbach
ResearchOpen Access19 Sept 2019
Nature Communications

Volume: 10, P: 1-18
U1 snRNP regulates cancer cell migration and invasion in vitro

U1 snRNP is a key regulator of mRNA biogenesis through its roles in splicing, and transcription and 3’-end processing. Here the authors show a tumor suppressor-like function of U1 snRNP using in vitro cell migration/invasion assays and transcriptome profiling.

Jung-Min Oh
Christopher C. Venters
Gideon Dreyfuss
ResearchOpen Access07 Jan 2020
Nature Communications

Volume: 11, P: 1-8

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Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage

NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers

Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture

U1 snRNP telescripting regulates a size–function-stratified human genome

Author Correction: Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

U1 snRNP regulates cancer cell migration and invasion in vitro

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