Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–25 of 25 results
Advanced filters: Author: Christopher Chapple Clear advanced filters

  • Overactive bladder (OAB) is a challenging clinical condition and treatment can include behavioral therapy or antimuscarinic agents. A placebo effect has been reported in randomized controlled studies of antimuscarinic agents for OAB. In this Review, Mangera and colleagues assess the response to placebo in OAB and describe a positive placebo effect in OAB outcome parameters. Reasons for the placebo effect and its potential use will also be discussed.

    • Altaf Mangera
    • Christopher R. Chapple
    • Melanie Plested
    Reviews
    Nature Reviews Urology
    Volume: 8, P: 495-503

  • When seeking a diagnosis in patients complaining of lower urinary tract symptoms there is a bewildering variety of questionnaires, symptom scales, measurements and urodynamic tests that can be utilized. The appropriate use of these different diagnostic tools and their associated strengths and weaknesses are discussed in this primer review by Christopher Chapple.

    • Christopher R Chapple
    Reviews
    Nature Clinical Practice Urology
    Volume: 2, P: 555-564

  • The number of individuals in a given space influences animal interactions and network dynamics. Here the authors identify general rules underlying density dependence in animal networks and reveal some fundamental differences between spatial and social dynamics.

    • Gregory F. Albery
    • Daniel J. Becker
    • Shweta Bansal
    Research
    Nature Ecology & Evolution
    Volume: 9, P: 2002-2013

  • Antimuscarinic drugs are the first-line treatment for overactive bladder. However, traditional formulations are associated with a number of adverse effects, most notably dry mouth. A study comparing a new topical gel formulation of oxybutynin to placebo has confirmed its efficacy and tolerability for treating overactive bladder.

    • Christopher R. Chapple
    News & Views
    Nature Reviews Urology
    Volume: 6, P: 351-352

  • Men with lower urinary tract symptoms frequently do not seek medical advice. For those who do, the traditional view of a solely prostatic origin might hinder management, since growing evidence suggests an important role for nonprostatic causes. This Review clarifies terminology for symptoms and causes and presents an overview of the available medical therapies.

    • Anand K Patel
    • Christopher R Chapple
    Reviews
    Nature Clinical Practice Urology
    Volume: 5, P: 211-219

  • A global dataset of the satellite-tracked movements of pelagic sharks and fishing fleets show that sharks—and, in particular, commercially important species—have limited spatial refuge from fishing effort.

    • Nuno Queiroz
    • Nicolas E. Humphries
    • David W. Sims
    Research
    Nature
    Volume: 572, P: 461-466

  • Fowler's syndrome is a cause of urinary retention in young women that is characterized by an abnormal electromyography reading from the external urethral sphincter. This Review, describing the aetiology, pathogenesis and management of Fowler's syndrome, will serve as a guide for urologists unfamiliar with this rare clinical problem.

    • Nadir I. Osman
    • Christopher R. Chapple
    Reviews
    Nature Reviews Urology
    Volume: 11, P: 87-98

  • Inflammatory and fibrotic responses to polypropylene mesh led to the withdrawal of this practice for treatment of stress urinary incontinence and pelvic organ prolapse in women in some countries. Improved material testing has been urged. We report poor responses of polypropylene mesh to repeated mechanical distension and macrophage interrogation. These results from preclinical in vitro testing show the potential of this approach for testing and improving materials before their introduction into the clinic.

    • Nicholas T. H. Farr
    • Victoria L. Workman
    • Cornelia Rodenburg
    Comments & Opinion
    Nature Reviews Urology
    Volume: 21, P: 515-516

  • Anterior urethral strictures are a common urological problem and urethrotomy has limited efficacy if repeated treatment is needed. An increasing number of studies have shown that mitomycin C has potential as an adjunct to urethrotomy for improving its success rate.

    • Joon J. Park
    • Tricia L. Kuo
    • Christopher R. Chapple
    Comments & Opinion
    Nature Reviews Urology
    Volume: 15, P: 717-718

  • A potential association between periodontitis, a chronic inflammatory disease characterized by loss of the periodontal ligament and alveolar bone, and systemic rheumatic diseases—particularly rheumatoid arthritis—has been suggested. Results from studies that support such a link are outlined in this article, as are causal and non-causal factors that could determine an association between the two conditions.

    • Paola de Pablo
    • Iain L. C. Chapple
    • Thomas Dietrich
    Reviews
    Nature Reviews Rheumatology
    Volume: 5, P: 218-224

  • Prolonged antibiotic treatment is often used clinically for patients with overactive bladder; however, this approach is contrary to existing recommendations regarding the prolonged non-specific use of antibiotics. In this Perspective, the authors consider the evidence — or lack thereof — for this approach and discuss how patients with overactive bladder should be managed.

    • Jelizaveta Pereca
    • Adrian Wagg
    • Christopher Chapple
    Reviews
    Nature Reviews Urology
    Volume: 22, P: 366-374

  • Detrusor underactivity (DUA) is a poorly understood bladder dysfunction without effective pharmacological treatments. This Review summarizes the available evidence relating to the aetiology and pathophysiology of DUA and highlights the need for further elucidation of the underlying mechanisms to enable the development of new treatment approaches.

    • Nadir I. Osman
    • Christopher R. Chapple
    Reviews
    Nature Reviews Urology
    Volume: 11, P: 639-648

  • An international consortium reports the genomic sequence for ten Drosophila species, and compares them to two other previously published Drosophila species. These data are invaluable for drawing evolutionary conclusions across an entire phylogeny of species at once.

    • Andrew G. Clark
    • Michael B. Eisen
    • Iain MacCallum
    Research
    Nature
    Volume: 450, P: 203-218

  • Achievement of global spatial targets for protected areas is not being matched by quality of management. This study quantifies current shortfalls in numbers of rangers and other personnel for those areas and assesses future requirements as more areas are set aside.

    • Michael R. Appleton
    • Alexandre Courtiol
    • Barney Long
    ResearchOpen Access
    Nature Sustainability
    Volume: 5, P: 1100-1110

  • Urethral injection of bulking agents or stem cell formulations are minimally invasive approaches to stress urinary incontinence. Hillary and colleagues summarize data on the efficacy and safety of bulking agents compared with conventional treatments, and discuss current knowledge of the use of stem cell formulations and acellular, stimulatory injection-based therapies for the treatment of this disorder.

    • Christopher J. Hillary
    • Sabiniano Roman
    • Christopher R. Chapple
    Reviews
    Nature Reviews Urology
    Volume: 17, P: 151-161

  • In this timeline, the authors describe the evolution of the use of polypropylene mesh in female pelvic floor surgery. They detail how the material properties of mesh relate to the occurrence of complications and discuss approaches to developing new materials and tissue engineering techniques.

    • Naşide Mangir
    • Betül Aldemir Dikici
    • Sheila MacNeil
    Reviews
    Nature Reviews Urology
    Volume: 16, P: 675-689