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Showing 1–6 of 6 results
Advanced filters: Author: Christopher D. Philipson Clear advanced filters

  • Circadian rhythms control many physiological functions. During periods of feeding, pancreatic islets secrete insulin to maintain glucose homeostasis — a rhythmic process that is disturbed in people with diabetes. These authors show that pancreatic islets contain their own clock: they have self-sustained circadian oscillations of CLOCK and BMAL1 genes and proteins, which are vital for the regulation of circadian rhythms. Without this clock, a cascade of cellular failure and pathology initiates the onset of diabetes mellitus.

    • Biliana Marcheva
    • Kathryn Moynihan Ramsey
    • Joseph Bass
    Research
    Nature
    Volume: 466, P: 627-631

  • Mast cells serve as sentinels for mucosal infection. This study shows how mast cells can differentially detect extracellular and invasive gut bacteria, and in response tune their cytokine production to signal different levels of danger.

    • Christopher von Beek
    • Anna Fahlgren
    • Mikael E. Sellin
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Widespread forest die-back due to the increasing frequency and intensity of drought in many parts of the planet is focusing attention on the mechanisms of tree drought resistance. This study provides direct experimental evidence that greater non-structural carbohydrate concentrations before drought help maintain hydraulic function and thereby prolong drought tolerance in seedlings of ten tropical tree species.

    • Michael J. O’Brien
    • Sebastian Leuzinger
    • Andy Hector
    Research
    Nature Climate Change
    Volume: 4, P: 710-714

  • Tree diversity is thought to benefit forest ecosystems, but evidence from large-scale studies is scarce. This study of a 400,000 km2forest area shows that higher tree species richness supports higher levels of multiple ecosystem services, and therefore also a more sustainable management of production forests.

    • Lars Gamfeldt
    • Tord Snäll
    • Jan Bengtsson
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-8

  • Around 48% of tree species in an aseasonal forest in Borneo, Malaysia had reduced growth during heavy rains, and 92% of species showed reduced survival, whereas as little as 4% of species had a decrease in growth or survival during dry periods during 2004–2017, according to an analysis of tree dynamics data from 25 tropical species.

    • Michael J. O’Brien
    • Andy Hector
    • Christopher D. Philipson
    ResearchOpen Access
    Communications Earth & Environment
    Volume: 5, P: 1-10