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Advanced filters: Author: Christopher James Petell Clear advanced filters

  • How histone modifications crosstalk with DNA methylation to regulate epigenomic patterning and genome stability in mammals remains elusive. Here, the authors show that DNA methyltransferase DNMT1 is a reader for histone H4K20 trimethylation via its BAH1 domain, which leads to optimal maintenance of DNA methylation at repetitive LINE-1 elements.

    • Wendan Ren
    • Huitao Fan
    • Jikui Song
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16