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Showing 1–9 of 9 results
Advanced filters: Author: Christopher K. E. Bleck Clear advanced filters

  • Assessing biological circuit connections in single cells has been intractable due to lack of appropriate tools. Here, Bleck et al. develop a method to assess mitochondrial network connectivity in muscle cells and observe clear differences consistent with differing energy requirements.

    • Christopher K. E. Bleck
    • Yuho Kim
    • Brian Glancy
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Mitochondrial networks are carefully positioned to facilitate energy distribution within muscle cells. Here they show that energetic demands and conserved transcription factors regulate mitochondrial network organization and contractile phenotypes independently in Drosophila.

    • Prasanna Katti
    • Peter T. Ajayi
    • Brian Glancy
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • How different physical configurations between sarcomeres and mitochondria alter energetic support for contractile function of skeletal muscle is not clear. Here the authors use advanced 3D imaging and analysis techniques to show how space is made for mitochondria within the tightly packed sarcomere networks of striated muscle cells.

    • Prasanna Katti
    • Alexander S. Hall
    • Brian Glancy
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Recent work has shown that mammalian muscle cells are comprised of multiple branching sarcomeres, though how this connectivity is regulated has remained unknown. Here the authors show three different mechanisms which regulate connectivity of the muscle contractile apparatus.

    • Peter T. Ajayi
    • Prasanna Katti
    • Brian Glancy
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Skeletal muscle cells have long been considered to be made primarily of many individual, parallel myofibrils. Here, the authors show that the striated muscle contractile machinery forms a highly branched, mesh-like myofibrillar matrix connected across the entire length and width of the muscle cell.

    • T. Bradley Willingham
    • Yuho Kim
    • Brian Glancy
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Monitoring the activity of the processive motor protein kinesin-1 in live cells is currently difficult. Here the authors report the fluorogenic small molecule QPD-OTf, a kinesin-1 substrate that causes activity-dependent dye precipitation.

    • Simona Angerani
    • Eric Lindberg
    • Nicolas Winssinger
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • While membrane contact sites between intracellular organelles are abundant, little is known about the contacts between membranes that delimit extracellular junctions within cells, such as intracellular parasites. Here authors demonstrate the segregation of a lipid transporter from a solute transporter in the malarial host-parasite interface.

    • Matthias Garten
    • Josh R. Beck
    • Joshua Zimmerberg
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Geiger and colleagues use SILAC and mass spectrometry to study protein turnover in human T cells and examine how naive T cells maintain their quiescence and transition to activated cells.

    • Tobias Wolf
    • Wenjie Jin
    • Roger Geiger
    Research
    Nature Immunology
    Volume: 21, P: 927-937