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Showing 1–4 of 4 results
Advanced filters: Author: Christopher K. Prier Clear advanced filters

  • The intermolecular amination of C–H bonds is an enabling transformation for the synthesis of nitrogen-containing molecules; however, developing catalysts for this class of reactions is very challenging. Now, an iron-based enzyme for this reaction has been engineered, demonstrating that a protein can confer a difficult new function upon an otherwise unreactive base metal.

    • Christopher K. Prier
    • Ruijie K. Zhang
    • Frances H. Arnold
    Research
    Nature Chemistry
    Volume: 9, P: 629-634

  • Using a combination of radical retrosynthesis, biocatalysis and C–H functionalization logic, a concise and scalable approach to the synthesis of saxitoxin and derivatives thereof in fewer than ten steps is presented.

    • Yinliang Guo
    • Yiheng Li
    • Phil S. Baran
    Research
    Nature
    Volume: 646, P: 351-357

  • Creating enzymes with new capabilities is a key goal for synthetic biology and sustainable chemistry. Now, computational approaches have been used to quickly achieve leaps in enzyme function, providing a versatile platform for biocatalytic hydroamination.

    • Christopher K. Prier
    News & Views
    Nature Catalysis
    Volume: 4, P: 348-349

  • Expanding the biocatalysis toolbox for C–N bond formation is of great value. Now, a biocatalytic amination strategy using a new-to-nature mechanism involving nitrogen-centred radicals has been developed. The transformations are enabled by synergistic photoenzymatic catalysis, providing intra- and intermolecular hydroamination products with high yields and levels of enantioselectivity.

    • Yuxuan Ye
    • Jingzhe Cao
    • Todd K. Hyster
    Research
    Nature Chemistry
    Volume: 15, P: 206-212