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Advanced filters: Author: Christopher M. Bobba Clear advanced filters

Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation

There are no targeted pharmacologic therapies to treat lung injury during mechanical ventilation (MV). Here the authors identify a mechanosensitive microRNA (miR-146a) in alveolar macrophages during MV and increase miR-146a to supraphysiological levels in these cells to mitigate ventilator induced lung injury.

Christopher M. Bobba
Qinqin Fei
Joshua A. Englert
ResearchOpen Access12 Jan 2021
Nature Communications

Volume: 12, P: 1-13
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

This work shows that treatments used for acute myeloid leukaemia and targeted therapies could be used for early T-cell precursor acute lymphoblastic leukaemia.

Jinghui Zhang
Li Ding
Charles G. Mullighan
ResearchOpen Access11 Jan 2012
Nature

Volume: 481, P: 157-163
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16

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