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Showing 301–350 of 452 results

Advanced filters: Author: Christopher M. Watson Clear advanced filters

Allelic deletions at chromosome 11q22-q23.1 and 11q25-qterm are frequent in sporadic breast but not colorectal cancers

John Koreth
Christopher J Bakkenist
James O'D McGee
Research30 Jan 1997
Oncogene

Volume: 14, P: 431-437
Observation of the rare B_s⁰ →µ⁺µ⁻ decay from the combined analysis of CMS and LHCb data

Combined analysis of proton-proton collision data from the Large Hadron Collider at CERN by the CMS and LHCb collaborations leads to the observation of the extremely rare decay of the strange B meson into muons; the result is compatible with the standard model of particle physics, and does not show any signs of new physics, such as supersymmetry.

V. Khachatryan
A.M. Sirunyan
E. Pesen
ResearchOpen Access13 May 2015
Nature

Volume: 522, P: 68-72
Effects of Antiglucocorticoid Treatment on 5-HT_1A Function in Depressed Patients and Healthy Subjects

Lawrence H Price
Angela Cappiello
George R Heninger
Research01 Oct 1997
Neuropsychopharmacology

Volume: 17, P: 246-257
Author Correction: Clonal haematopoiesis and risk of chronic liver disease

Waihay J. Wong
Connor Emdin
Pradeep Natarajan
Amendments and Corrections03 Jul 2023
Nature

Volume: 619, P: E47
Prediction of human population responses to toxic compounds by a collaborative competition

Crowdsourcing analysis improves computational prediction of cytotoxic responses in humans.

Federica Eduati
Lara M Mangravite
Julio Saez-Rodriguez
ResearchOpen Access01 Sept 2015
Nature Biotechnology

Volume: 33, P: 933-940
Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Amendments and Corrections21 May 2021
Nature Medicine

Volume: 27, P: 1116
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett
Joe Grove
Emma C. Thomson
Amendments and CorrectionsOpen Access16 Sept 2022
Nature Microbiology

Volume: 7, P: 1709
Two Doses of Early Intravenous Dexamethasone for the Prevention of Bronchopulmonary Dysplasia in Babies with Respiratory Distress Syndrome

Raymond J Sanders
Christopher Cox
Robert A Sinkin
Research01 Jul 1994
Pediatric Research

Volume: 36, P: 122-128
An Earth-sized planet with an Earth-like density

Data from the Kepler spacecraft and the HARPS-N ground-based spectrograph indicate that the extrasolar planet Kepler-78b has a mean density similar to that of Earth and imply that it is composed of rock and iron.

Francesco Pepe
Andrew Collier Cameron
Christopher A. Watson
Research30 Oct 2013
Nature

Volume: 503, P: 377-380
Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

PTPN2 (protein tyrosine phosphatase non-receptor type 2) and PTPN1 are attractive immuno-oncology targets, however, targeting PTPN2/N1 poses significant challenges. Here, the authors report the development of potent PTPN2/N1 heterobifunctional degraders and reveal biochemical and structural insights into the formation of ternary structures with cereblon E3 ligase by X-ray diffraction, cryo-EM and MD simulations.

Qi Hao
Manoj K. Rathinaswamy
Michael E. Kort
ResearchOpen Access16 Aug 2024
Communications Chemistry

Volume: 7, P: 1-16
Nanotechnology to advance CRISPR–Cas genetic engineering of plants

Despite its high promise, there are still many challenges for CRISPR-mediated plant genetic engineering, yet nanotechnology can play an important role in lowering and possibly eliminating these challenges.

Gozde S. Demirer
Tallyta N. Silva
Markita P. Landry
Reviews12 Mar 2021
Nature Nanotechnology

Volume: 16, P: 243-250
Perspectives on ENCODE

The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases.

Federico Abascal
Reyes Acosta
Richard M. Myers
Reviews29 Jul 2020
Nature

Volume: 583, P: 693-698
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection.

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 270-278
Erratum: The RA-MAP Consortium: a working model for academia–industry collaboration

Andrew P. Cope
Michael R. Barnes
James Butler
Amendments and Corrections24 Jan 2018
Nature Reviews Rheumatology

Volume: 14, P: 119
How insulin engages its primary binding site on the insulin receptor

The three-dimensional structure of the insulin–insulin receptor complex has proved elusive, confounded by the complexity of producing the receptor protein; here is the first glimpse of the interaction between insulin and its primary binding site on the insulin receptor, a view based on four crystal structures of insulin bound to truncated insulin receptor complexes.

John G. Menting
Jonathan Whittaker
Michael C. Lawrence
Research09 Jan 2013
Nature

Volume: 493, P: 241-245
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

Peter Donnelly and colleagues report a genome-wide association study for Barrett's esophagus, a common premalignant condition associated with stomach acid reflux and predisposing to esophageal adenocarcinoma. They identify two loci associated with susceptibility to Barrett's esophagus.

Zhan Su
Laura J Gay
Janusz A Z Jankowski
Research09 Sept 2012
Nature Genetics

Volume: 44, P: 1131-1136
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

Sema Nickbakhsh
Joseph Hughes
Alison Smith-Palmer
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-17
Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin

A functional genomics approach in patient derived cell lines of Favorable Histology Wilms Tumor identifies suppression of TRIP13 through the nuclear export inhibitor, KPT-330, leads to decreased viability and synergy with doxorubicin.

Karuna Mittal
Garrett W. Cooper
Andrew L. Hong
ResearchOpen Access08 Apr 2024
Communications Biology

Volume: 7, P: 1-13
Tracking U.S. Pertussis Incidence: Correlation of Public Health Surveillance and Google Search Data Varies by State

Christopher H. Arehart
Michael Z. David
Vanja Dukic
ResearchOpen Access24 Dec 2019
Scientific Reports

Volume: 9, P: 1-10
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

Detailed analyses of siRNA delivery by lipid nanoparticles reveal major pathways of siRNA internalization and endosomal escape.

Gaurav Sahay
William Querbes
Daniel G Anderson
Research23 Jun 2013
Nature Biotechnology

Volume: 31, P: 653-658
Brain metabolic changes and clinical response to superolateral medial forebrain bundle deep brain stimulation for treatment-resistant depression

Christopher R. Conner
Joao Quevedo
Albert J. Fenoy
Research19 Aug 2022
Molecular Psychiatry

Volume: 27, P: 4561-4567
Can AlphaFold’s breakthrough in protein structure help decode the fundamental principles of adaptive cellular immunity?

This Perspective discusses the potential of protein structure-prediction models for exploring the structural landscape and specificity of TCR–pMHC interactions.

Benjamin McMaster
Christopher Thorpe
Hashem Koohy
Reviews23 Apr 2024
Nature Methods

Volume: 21, P: 766-776
Herbal interventions for chronic asthma in adults and children: a systematic review and meta-analysis

Christopher E Clark
Elizabeth Arnold
Taixiang Wu
Reviews18 Jul 2010
Primary Care Respiratory Journal

Volume: 19, P: 307-314
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
A Myb dependent pathway maintains Friend murine erythroleukemia cells in an immature and proliferating state

Jing Chen
Christopher S Kremer
Timothy P Bender
Research13 Mar 2002
Oncogene

Volume: 21, P: 1859-1869
Corneal endothelial precipitates in HIV- and CMV- positive patients without concomitant ocular disease

Anita I Miedziak
Christopher J Rapuano
Stephen Goldman
Correspondence01 Jul 1998
Eye

Volume: 12, P: 743-745
FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes

Mutations in the transcription factor FOXA1 that are common in prostate cancer result in gain-of-function effects that promote changes in the differentiation of tumour cells.

Elizabeth J. Adams
Wouter R. Karthaus
Charles L. Sawyers
Research26 Jun 2019
Nature

Volume: 571, P: 408-412
AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula

A preclinical study in mice suggests important roles for a scaffold protein, A-kinase anchoring protein 150 (AKAP150) in regulation of synaptic function, glutamatergic plasticity and intrinsic excitability of lateral habenula (LHb) neurons.

Sarah C. Simmons
William J. Flerlage
Fereshteh S. Nugent
ResearchOpen Access20 Mar 2024
Communications Biology

Volume: 7, P: 1-14
Genome engineering: a new approach to gene therapy for neuromuscular disorders

Genome engineering tools, including targeted gene editing and gene regulation, are becoming available to correct the mutations that cause neuromuscular disorders such as muscular dystrophy, spinal muscular atrophy and myotonic dystrophy. This Review summarizes the genome engineering strategies that are under preclinical evaluation for the treatment of degenerative neuromuscular disorders, focusing on the tools that show the greatest potential for clinical translation.

Christopher E. Nelson
Jacqueline N. Robinson-Hamm
Charles A. Gersbach
Reviews29 Sept 2017
Nature Reviews Neurology

Volume: 13, P: 647-661
Therapies for rare diseases: therapeutic modalities, progress and challenges ahead

Most rare diseases still lack approved treatments. This article analyses the main therapeutic modalities available to researchers interested in translating advances in the scientific understanding of rare diseases into therapies, highlights progress so far and discusses overarching issues in drug development for rare diseases.

Erik Tambuyzer
Benjamin Vandendriessche
Marco Prunotto
Reviews13 Dec 2019
Nature Reviews Drug Discovery

Volume: 19, P: 93-111
A government-led effort to identify correlates of protection for COVID-19 vaccines

Richard A. Koup
Ruben O. Donis
Christopher R. Houchens
Correspondence13 Sept 2021
Nature Medicine

Volume: 27, P: 1493-1494
Author Correction: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

Evan Bolyen
Jai Ram Rideout
J. Gregory Caporaso
Amendments and Corrections09 Aug 2019
Nature Biotechnology

Volume: 37, P: 1091
DNA origami presenting the receptor binding domain of SARS-CoV-2 elicit robust protective immune response

A DNA origami nanoparticle-based vaccine against SARS-Cov-2 co-delivers viral RBD antigen and CpG adjuvant and elicits a robust protective immunity against the virus in a mouse model.

Esra Oktay
Farhang Alem
Remi Veneziano
ResearchOpen Access23 Mar 2023
Communications Biology

Volume: 6, P: 1-11
Defining tissue proteomes by systematic literature review

Sarah A. Hibbert
Matiss Ozols
Michael J. Sherratt
ResearchOpen Access11 Jan 2018
Scientific Reports

Volume: 8, P: 1-10
Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes

Alexander G. Bick
Joshua S. Weinstock
Pradeep Natarajan
Amendments and Corrections11 Mar 2021
Nature

Volume: 591, P: E27
Altered grey matter structural covariance in chronic moderate–severe traumatic brain injury

Georgia F. Symons
Matthew C. Gregg
Gershon Spitz
ResearchOpen Access19 Jan 2024
Scientific Reports

Volume: 14, P: 1-12
Author Correction: A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

G. Aad
B. Abbott
L. Zwalinski
Amendments and CorrectionsOpen Access18 Oct 2023
Nature

Volume: 623, P: E5
A strategy for co-translational folding studies of ribosome-bound nascent chain complexes using NMR spectroscopy

Cassaignau et al. provide a strategy for large-scale production and analysis of translationally arrested, isotopically labelled ribosome-bound nascent chains, enabling high-resolution co-translational protein folding studies using NMR spectroscopy.

Anaïs M E Cassaignau
Hélène M M Launay
Lisa D Cabrita
Protocols28 Jul 2016
Nature Protocols

Volume: 11, P: 1492-1507
IFITM3 restricts the morbidity and mortality associated with influenza

Interferon-inducible transmembrane (IFITM) protein 3 is shown to be an innate defence mechanism against viral infection in vivo; furthermore, a subset of the patients hospitalized during the H1N1 2009 pandemic carried a variant form of the IFITM3 gene.

Aaron R. Everitt
Simon Clare
Paul Kellam
Research25 Mar 2012
Nature

Volume: 484, P: 519-523
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

Dan Nicolae, Carole Ober and colleagues report a meta-analysis of genome-wide association studies for asthma in a collection of ethnically diverse North American populations. They identify a newly associated susceptibility locus at PYHIN1 in individuals of African descent.

Dara G Torgerson
Elizabeth J Ampleford
Dan L Nicolae
Research31 Jul 2011
Nature Genetics

Volume: 43, P: 887-892
Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States

Detailed clinical and virologic characteristics of the first 12 individuals with COVID-19 in the United States from the US Centers for Disease Control and Prevention.

Stephanie A. Kujawski
Karen K. Wong
Jing Zhang
Research23 Apr 2020
Nature Medicine

Volume: 26, P: 861-868
Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice

Ruby Chrisp
Mitchell Masterson
Paula M. Moran
ResearchOpen Access11 Mar 2025
Scientific Reports

Volume: 15, P: 1-15
Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors

Christopher Fitzpatrick
Maximiliano F. Bendek
Verónica A. Burzio
ResearchOpen Access29 May 2019
Cell Death & Disease

Volume: 10, P: 1-12
Initial sequencing and analysis of the human genome

Eric S. Lander
Lauren M. Linton
Michael J. Morgan
articles01 Feb 2001
Nature

Volume: 409, P: 860-921
Global optimization of somatic variant identification in cancer genomes with a global community challenge

Paul C Boutros
Adam D Ewing
Joshua M Stuart
CorrespondenceOpen Access27 Mar 2014
Nature Genetics

Volume: 46, P: 318-319
Collection of lymph-borne dendritic cells in the rat

Simon WF Milling
Christopher Jenkins
Gordon MacPherson
Protocols21 Dec 2006
Nature Protocols

Volume: 1, P: 2263-2270
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Naomi Wray and colleagues report an analysis of genome-wide association data sets from the Psychiatric Genomics Consortium for five psychiatric disorders. They find that common variation explains 17–29% of the variance in liability and provide further support for a shared genetic etiology for these related psychiatric disorders.

S Hong Lee
Stephan Ripke
Naomi R Wray
Research11 Aug 2013
Nature Genetics

Volume: 45, P: 984-994
Dehydration-Rehydration Vesicles: A Simple Method for High Yield Drug Entrapment in Liposomes

Christopher Kirby
Gregory Gregoriadis
Research01 Nov 1984
Bio/Technology

Volume: 2, P: 979-984
The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program

Michael P. Harms
Kang-Ik K. Cho
Ofer Pasternak
ResearchOpen Access02 Apr 2025
Schizophrenia

Volume: 11, P: 1-14
Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP)

Chuan-Hsiung Chang
Gary K Scott
Christopher C Benz
Research14 Jul 1999
Oncogene

Volume: 18, P: 3682-3695

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