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Food pantries are part of the emergency food network in the United States, but they are an understudied component of food access. The Pantry Accessibility Index and Individual Accessibility Index developed here allow measurement of the spatiotemporal availability of these services to the food insecure of south-central Indiana.

The phenotype and function of immune cells could change during spaceflight. Here the authors use simulated microgravity, coupled to validation with spaceflight data, to assess whether there are distinct gene expression changes in resting and TLR 7/8 stimulated PBMCs and found conserved changes in IFN signalling, the cytoskeleton, IL-6 and sirtuin signalling.

Large-scale OMICs investigations of biological systems can be used to predict functional relationships between compounds, genes and proteins. Here, the authors develop a deep learning-based approach that significantly increases the number of high-quality compound-target predictions relative to existing methods.

Quantum simulations of topological insulator phases with single-site control would allow to see richer phenomenology. Using a programmable trapped-ion simulator with site-resolved Floquet control, the authors implement a long-range spin model, revealing protected edge excitations and rich many-body dynamics beyond the single-excitation regime.

Nipah virus (NiV) can be transmitted from bats and other animals to humans, causing severe encephalitis and respiratory disease. Here, Satterfield et al.show that the W protein of NiV modulates the host immune response and determines disease course in a ferret model of infection.

Remotely controlled experiments are the way forward.

Using a trapped-ion quantum simulator of up to 50 spins, researchers explore new universal scaling laws in non-equilibrium dynamics, revealing unique critical behaviors following a sequence of quenches in a long-range 1D Ising model.

Understanding the pathology in the lungs of patients with COVID-19 might provide clues as to the susceptibility of patients and how the SARS-CoV-2 virus can be fatal. Here the authors analyze cadaveric pulmonary tissue and show one group with high viral load, early death, inflammation and inflammatory damage, and another with low viral load, longer duration of disease, and more M2-like polarization and fibrotic lung damage.

In this paper, the authors show high-fidelity entanglement of 97% between remote trapped ion memories, mediated by time-bin photons. The time-bin nature of photons removes polarization errors and allows extension to higher dimensional qubit memories.

Sex differences in fasting glucose and insulin have been identified, but the genetic loci underlying these differences have not. Here, the authors perform a meta-analysis of genome-wide association studies to detect sex-specific and sex-dimorphic loci associated with fasting glucose and insulin.

Previous work has shown in iPSC derived neurons that synaptic impairments are associated with a 4bp DISC1 deletion. Here the authors demonstrate a role for the PDE4 signalling pathway in these synaptic impairments.

Coherent noise affecting a random error correcting code is now shown to produce a transition between phases that accumulate and destroy magic.

Cyclic-di-GMP is a bacterial second messenger that binds to the regulatory domain of ATPases of some bacteria. Here, the authors report the crystal structure of this interaction, identify a cyclic-di-GMP binding mode, and show that this interaction might be important for bacterial biofilm formation.

Artificial reefs provide important ecosystem services in marine environments. Accurate knowledge of the area covered by such reefs can help evaluate benefits and risks of such structures. This study describes the physical footprint of artificial reefs deployed in coastal waters of the United States.

How the diversity and number of neuronal subtypes across species drives neocortical size and complexity remains incompletely understood. Here authors demonstrate BRN1/2 act in concert with NOTCH and primary microcephaly genes to regulate evolutionarily conserved neocortical progenitor behavior across species and determine brain size.

Multiomics analysis of right colon tissues identifies a distinct immune gene signature associated with greater risk of and shorter time to dysplasia in patients with primary sclerosing cholangitis, but not in patients with inflammatory bowel disease.

Temporal multi-omic analysis of tissues from rats undergoing up to eight weeks of endurance exercise training reveals widespread shared, tissue-specific and sex-specific changes, including immune, metabolic, stress response and mitochondrial pathways.

Long-range interactions have been predicted to enable a phase transition in one-dimensional systems. An experiment now validates this hypothesis in a trapped-ion quantum simulator by observing a finite-energy phase transition in one dimension.

Multi-ancestry meta-analyses of genome-wide association studies for self-reported physical activity during leisure time, leisure screen time, sedentary commuting and sedentary behavior at work identify 99 loci associated with at least one of these traits.

Fault-tolerant circuits for the control of a logical qubit encoded in 13 trapped ion qubits through a Bacon–Shor quantum error correction code are demonstrated.

Generation of entanglement in quantum computers stems from the native interactions between qubits, which are usually restricted to the pairwise limit. A method to control three- and four-body interactions has now been demonstrated with trapped ions.

Today's take on the stem-cell field could recede rapidly in tomorrow's rear-view mirror.

Thousands of recombinant antibodies enriched for specificity against defined targets are assembled in multivalent mixtures with enhanced therapeutic activity.

A one-dimensional trapped-ion quantum simulator with up to 23 spins is used to demonstrate a continuous symmetry-breaking phase that relies on long-range interactions.

The genome of the biofuel crop switchgrass (Panicum virgatum) reveals climate–gene–biomass associations that underlie adaptation in nature and will facilitate improvements of the yield of this crop for bioenergy production.

Cathy Laurie and colleagues detect mosaicism for large chromosomal abnormalities in peripheral blood in a subset of healthy individuals. They show that the frequency of such events increases with age and is associated with elevated risk of developing a subsequent hematological cancer.

It is known that exercise influences many human traits, but not which tissues and genes are most important. This study connects transcriptome data collected across 15 tissues during exercise training in rats as part of the Molecular Transducers of Physical Activity Consortium with human data to identify traits with similar tissue specific gene expression signatures to exercise.

Induction of APOBEC3A in response to targeted therapies drives evolution of drug-tolerant persister cells, suggesting that its suppression may represent a potential therapeutic strategy in the prevention of acquired resistance to lung cancer targeted therapy.

Being able to perform qubit measurements within a quantum circuit and adapt to their outcome broadens the power of quantum computers. These mid-circuit measurements have now been used to implement a cryptographic proof of non-classical behaviour.

Keri Monda, Kari North, Christopher Haiman and colleagues report a meta-analysis of GWAS for body mass index that is composed of 39,144 individuals of African ancestry, followed by further genotyping in 32,268 individuals of African ancestry. The study also includes analysis of publicly available data from the GIANT consortium of ~124,000 individuals of European ancestry. The paper reports evidence for two new loci near GALNT10 and MIR148A.

Implementations of quantum walks on ion trap quantum computers have been so far limited to the analogue simulation approach. Here, the authors implement a quantum-circuit-based discrete quantum walk in one-dimensional position space, realizing a Dirac cellular automaton with tunable mass parameter.

A risk haplotype for type 2 diabetes is identified with four amino acid substitutions in SLC16A11, which is present at ∼50% frequency in Native American samples and ∼10% in east Asian samples, but is rare in European and African samples; SLC16A11 may alter hepatic lipid metabolism, causing an increase in triacylglycerol levels.

Christopher Haiman and colleagues report a genome-wide association study for prostate cancer in African-American males drawn from 11 epidemiological studies of prostate cancer, with replication including individuals of African ancestry from 10 additional studies worldwide. They identify a new susceptibility locus on chromosome 17q21, for which the risk allele shows a higher frequency in men of African ancestry than in other populations. This may explain some of the increased incidence of prostate cancer in men of African ancestry.

Using a multi-omics approach, the authors examine the molecular drivers of sexual dimorphism in the subcutaneous adipose tissue from sedentary and endurance-trained rats. These data provide a valuable resource for adipose tissue-related research.

Early-onset familial Alzheimer’s disease mutations induce both amyloid-β and tau pathologies in differentiated human neural stem cells in 3D cultures.

Chromodomain Helicase DNA-binding (CHD) proteins have been implicated in neurodevelopmental processes. Here, the authors identify missense variants in CHD3 that disturb its chromatin remodeling activities and cause a neurodevelopmental disorder with macrocephaly and speech and language impairment.

OTX2 promotes tumour growth in Group 3 medulloblastoma. Here, the authors show that OTX2 regulates PAX3 to induce neural de-differentiation and promote tumourigenesis in Group 3 medulloblastoma.

Carefully crossed laser beams can hold cool atoms in a lattice, sitting at the point of constructive interference between the beams, one wavelength apart. Because they are under such precise external control, these optical lattices allow some textbook solid-state physics phenomena to be observed cleanly. Now they are also being used to push at the apparent barriers of quantum mechanics -- to transiently squeeze atoms to a smaller size than the usual quantum limit, for example.

Many-body open quantum systems are predicted to undergo a phase transition towards a pure state through frequent projective measurements. The phases separated by this transition have now been observed with random circuits on a trapped-ion computer.