Nature Search

WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity

Tissue-resident macrophages (TRM) are important mediators of local immunity. Here the authors show that the deficiency or inhibition of a kinase, WNK1, unlinks macrophage colony-stimulating factor signaling and resulted macropinocytosis with the downstream, potentially IRF8-mediated genetic program to bias progenitor differentiation to neutrophil instead of TRM.

Alissa J. Trzeciak
Zong-Lin Liu
Justin S. A. Perry
ResearchOpen Access28 May 2025
Nature Communications

Volume: 16, P: 1-19
Early life high fructose impairs microglial phagocytosis and neurodevelopment

Exposure of mice to high fructose during gestation or early postnatal life causes decreased microglial phagocytosis during brain development and leads to anxiety-like behaviour in adolescence.

Zhaoquan Wang
Allie Lipshutz
Justin S. A. Perry
Research11 Jun 2025
Nature

Volume: 644, P: 759-768
CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammation

Artis and colleagues show that enteric neurons produce CGRP-related ADM2 to promote intestinal tissue-protective functions in ILC2s.

Jazib Uddin
Hiroshi Yano
David Artis
Research15 Aug 2025
Nature Immunology

Volume: 26, P: 1516-1526
Host metabolism balances microbial regulation of bile acid signalling

A family of host-derived bile acid–methylcysteamine conjugates functions as FXR antagonists, forming part of a microbiota-dependent metabolic network that regulates FXR-dependent physiology.

Tae Hyung Won
Mohammad Arifuzzaman
Frank C. Schroeder
Research08 Jan 2025
Nature

Volume: 638, P: 216-224
Influence of coupling of sorption and photosynthetic processes on trace element cycles in natural waters

Christopher C. Fuller
James A. Davis
Research06 Jul 1989
Nature

Volume: 340, P: 52-54
Joint single-cell measurements of nuclear proteins and RNA in vivo

This work describes inCITE-seq that jointly measures intranuclear protein levels and the transcriptome in single nuclei, which is applied to mouse brain tissue to relate quantitative protein levels of TFs to gene expression programs.

Hattie Chung
Christopher N. Parkhurst
Aviv Regev
Research04 Oct 2021
Nature Methods

Volume: 18, P: 1204-1212
Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19

Iliev et al. report that increased Candida albicans accumulation in the mycobiota of patients with severe COVID-19 might be a contributing factor to the immunopathology of severe COVID-19 and have long-lasting effects on the hematopoietic stem cell compartment.

Takato Kusakabe
Woan-Yu Lin
Iliyan D. Iliev
Research23 Oct 2023
Nature Immunology

Volume: 24, P: 1879-1889
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

Heather J. Cordell
Younghun Han
Katherine A. Siminovitch
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation

Dietary inulin fibre alters the composition and metabolism of gut microbiota, resulting in elevated levels of bile acids that subsequently trigger mucosal type 2 inflammation characterized by eosinophilia, with clinical implications for allergy and anti-helminth defence.

Mohammad Arifuzzaman
Tae Hyung Won
David Artis
Research02 Nov 2022
Nature

Volume: 611, P: 578-584
Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces

The development of a new genetic tool to selectively deplete or modify group 2 innate lymphoid cells (ILC2s) addresses the debate regarding the non-redundant functions of this immune cell type.

Amy M. Tsou
Hiroshi Yano
David Artis
Research02 Nov 2022
Nature

Volume: 611, P: 787-793
Antigen-presenting innate lymphoid cells orchestrate neuroinflammation

A subset of inflammatory group 3 innate lymphoid cells, here termed iILC3s, infiltrate the central nervous system and promote neuroinflammation and disease progression in a mouse model of multiple sclerosis.

John B. Grigg
Arthi Shanmugavadivu
Gregory F. Sonnenberg
Research01 Dec 2021
Nature

Volume: 600, P: 707-712
The microbiota regulate neuronal function and fear extinction learning

A diverse intestinal microbiota is required for mice to undergo extinction-related neuronal plasticity and normal fear extinction learning.

Coco Chu
Mitchell H. Murdock
David Artis
Research23 Oct 2019
Nature

Volume: 574, P: 543-548
Nuclear F-actin and myosins drive relocalization of heterochromatic breaks

Relocalization of heterochromatic double-strand breaks to the nuclear periphery in Drosophila cells occurs via directed motions driven by nuclear actin filaments and myosins activated by the Smc5/6 complex.

Christopher P. Caridi
Carla D’Agostino
Irene Chiolo
Research20 Jun 2018
Nature

Volume: 559, P: 54-60
PDGF signaling specificity is mediated through multiple immediate early genes

This is an issue edsumm for ng1922. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence. It shows that sea surface temperatures near the North Pole increased from roughly 18 degrees Celsius to over 23 degrees Celsius — such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming.

Jennifer Schmahl
Christopher S Raymond
Philippe Soriano
Research03 Dec 2006
Nature Genetics

Volume: 39, P: 52-60
Paths to stemness: building the ultimate antitumour T cell

Treating cancer patients with T cell-based therapies has shown some some promise in the clinic, but not all patients respond. There could be many reasons for this, some of which might be addressed by using the best possible antitumour T cell. What are the biological properties of such a cell and can we generate one?

Luca Gattinoni
Christopher A. Klebanoff
Nicholas P. Restifo
Reviews21 Sept 2012
Nature Reviews Cancer

Volume: 12, P: 671-684
Thinned-skull cranial window technique for long-term imaging of the cortex in live mice

Guang Yang
Feng Pan
Wen-Biao Gan
Protocols14 Jan 2010
Nature Protocols

Volume: 5, P: 201-208

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