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Showing 1–6 of 6 results
Advanced filters: Author: Christopher P. Toseland Clear advanced filters

  • The actin-based molecular motors, myosins, have also been linked to transcription, but their precise role has remained elusive. Here the authors show RNA polymerase II (RNAPII) is lost from chromatin upon myosin perturbation and that myosin acts as a molecular anchor to maintain RNAPII spatial organisation.

    • Yukti Hari-Gupta
    • Natalia Fili
    • Christopher P. Toseland
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • An autophagy receptor, NDP52, is recruited to the nucleus where it can bind DNA. The authors show this promotes changes in chromatin accessibility which supports transcription initiation, providing a direct link between autophagy and transcription regulation.

    • Ália dos Santos
    • Daniel E. Rollins
    • Christopher P. Toseland
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-24

  • Myosin VI (MVI) is known to interact with RNA Polymerase II and to play non-cytoplasmic roles in cells. Here, the authors provide evidence that the transcription co-activator NDP52 regulates MVI binding to DNA and that MVI interacts with nuclear receptors to drive gene expression.

    • Natalia Fili
    • Yukti Hari-Gupta
    • Christopher P. Toseland
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • Talin is a mechanosensing cytoplasmic adaptor that links integrin cell adhesion receptors to the actin cytoskeleton. Here the authors measure the force-dependent folding and refolding kinetics of all talin rod domains to propose that talin can function as a force buffer under physiologically relevant conditions.

    • Mingxi Yao
    • Benjamin T. Goult
    • Jie Yan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • The genome of the Southern Ocean phytoplankton Fragilariopsis cylindrus differs markedly from the genomes of its more temperate relatives, with divergent alleles being differentially expressed in environmentally specific conditions such as freezing and darkness.

    • Thomas Mock
    • Robert P. Otillar
    • Igor V. Grigoriev
    ResearchOpen Access
    Nature
    Volume: 541, P: 536-540