Nature Search

Realizing the potential of agonistic antibody immunotherapy

Agonistic antibodies initiate signalling by the receptors they target, mimicking the activities of native ligands. This Review discusses the clinical successes and failures of agonistic antibodies and explains how recent mechanistic insights should broaden the scope and improve the safety and efficacy of immunotherapies based on these agents.

Mark S. Cragg
Xiaojie Yu
Simon J. Davis
Reviews19 May 2026
Nature Reviews Drug Discovery

P: 1-20
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations at this locus to breast or ovarian cancer susceptibility and report functional studies in breast and ovarian cancer tissue and cell lines.

Stig E Bojesen
Karen A Pooley
Alison M Dunning
Research27 Mar 2013
Nature Genetics

Volume: 45, P: 371-384
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

The inhibitory receptor CTLA-4 recognizes two ligands on opposing antigen-presenting cells, CD80 and CD86. Sansom and colleagues show CTLA-4 captures ligands by transendocytosis, whereupon low-affinity CD86 releases CTLA-4 at low pH to promote CTLA-4 recycling; however, high-affinity CD80 remains bound and targets CTLA-4 for ubiquitination and destruction.

Alan Kennedy
Erin Waters
David M. Sansom
ResearchOpen Access23 Aug 2022
Nature Immunology

Volume: 23, P: 1365-1378
Single-cell transcriptomic analysis of retinal immune regulation and blood-retinal barrier function during experimental autoimmune uveitis

Joel Quinn
Ahmed Salman
Kanmin Xue
ResearchOpen Access28 Aug 2024
Scientific Reports

Volume: 14, P: 1-14

Quick links

Search

Filter By:

Realizing the potential of agonistic antibody immunotherapy

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

Single-cell transcriptomic analysis of retinal immune regulation and blood-retinal barrier function during experimental autoimmune uveitis

Search

Quick links