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Showing 1–4 of 4 results
Advanced filters: Author: Christopher R. Fullenkamp Clear advanced filters

  • Targeting individual DNA secondary structures in the genome with small molecules is challenging. Here, the authors develop ATENA, a CRISPR-based platform for targeting specific DNA structures in cells with high precision, helping to elucidate their biological roles and guide therapeutic design.

    • Sabrina Pia Nuccio
    • Enrico Cadoni
    • Marco Di Antonio
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-23

  • Fluorogenic RNA aptamers such as Mango are powerful tools for RNA imaging. An ultrabright RNA-activated fluorophore with improved photophysical performance has now been developed using a structure-informed, fragment-based screening approach. This system was studied using high-resolution crystallography and applied to image RNA in cells.

    • Mo Yang
    • Peri R. Prestwood
    • John S. Schneekloth Jr
    Research
    Nature Chemistry
    Volume: 17, P: 1188-1195

  • Medicinal chemistry efforts typically focus on drug–protein interactions and overlook RNA binding as a source of off-target pharmacology. Now, a new method has been developed to map the interactions of small-molecule drugs with RNA in cells and characterize how these interactions can exert functional effects.

    • Christopher R. Fullenkamp
    • John S. Schneekloth Jr
    News & Views
    Nature Chemistry
    Volume: 15, P: 1329-1331

  • The systemic immune features that distinguish COVID-19 from common infections remain incompletely elucidated. Here McClain et al. compare RNA sequencing in peripheral blood between subjects with SARS-CoV-2 and other respiratory infections and demonstrate dysregulated immune responses in COVID-19 with both heterogeneous and conserved components.

    • Micah T. McClain
    • Florica J. Constantine
    • Christopher W. Woods
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8